Happy Black Friday, everyone! One of the best online retailers to look up for the best Black Friday fitness deals is Best Buy. The best Best Buy fitness deals include Apple Watch Series 5 offers, cheap Theragun percussion massager deals and a great rowing machine discount.
• Shop all ‘Smartwatch, Health & Fitness Tech’ Black Friday deals at Best Buy
Currently, the best offers are on fitness wearables, home gym equipment and percussion massage devices. For even more deals, check out the best Garmin Black Friday deals, all the best deals from the Fitbit Black Friday Sale plus the best Black Friday treadmill deals, best Black Friday exercise bike deals and best Black Friday elliptical deals.
Best Best Buy fitness deals on today
Apple Watch Series 5 Nike Edition | Was $429 | Now $329 | Save $100 at Best Buy
Apple is super keen on infusing its Watch series with more fitness features but even without the fitness bits, the Apple Watch Series 5 is ultra-precise and capable smartwatch. It comes with built-in GPS, always-on Retina display, 30% larger screen (compared to Series 3), ECG app, electrical and optical heart sensors, compass, fall detection and emergency SOS. And now it’s $100 cheaper, get this deal NOW!View Deal
Theragun Elite Percussive Massager | Was $ 399 | Now $299 | You save $100 at Best Buy
Theragun is a percussion massager household name and the Elite is probably the best massage gun for non-professional athletes. With the discount, you can get this Bluetooth enabled handheld massager for just under $300. The latest Theragun range is quieter than before but equally as powerful than the previous generation devices. Programmes can be initiated straight from the free-of-charge Therabody App.View Deal
Hydrow Connected Rower | Was $2,245 | Now $1,995 | Save $250 at Best Buy
Not a particularly cheap rowing machine, yet the Hydrow is now $250 off on black Friday at Best Buy. Stream live workouts or browse the 1000-strong workout library on the Hydrow’s 22″ HD touchscreen monitor. This quiet rowing machine is a joy to look at and use, a great deal from Best Buy!View Deal
Black Friday sales around the web (US)
- Apple – see the latest Apple offers here
- Best Buy – massive savings across every department
- Dell.com – save big on notebooks, desktops, monitors and more
- eBay.com – big discounts in the eBay Brand Outlet
- Home Depot – save on furniture, smart home devices and more
- HP – save up to 30% on select products
- Lowes – save up to $500 on select appliances
- Lenovo – deep discounts on gaming laptops, student laptops and more
- Microsoft – Surface and Xbox deals plus Microsoft Store Exclusives
- Newegg – get your computer parts for less
- Nordstrom – deals on Hunter, UGG, The North Face and more
- Target – Target is going big on Black Friday this year
- Walmart – save big on tech, home appliances and much more
T3 guides to the Black Friday sales
Philadelphia COVID-19 today: Philadelphia Fitness Coalition protesting gym closures in city amid coronavirus pandemic
They have created the Philadelphia Fitness Coalition and have gathered more than 1,500 signatures in opposition to the new restrictions.
As the number of covid-19 cases rises, the city required gyms to shut down indoor activities at the end of last week.
But gym owners say it is unfair because of the safety precautions they have put in place.
They plan to protest outside of City Hall on Tuesday.
Last week, the city’s top health official, Dr. Thomas Farley, defended the city’s decision to tighten restrictions, saying now is the riskiest time for the transmission of the virus.
“What was now safe is now dangerous with the change in the weather. Many businesses feel they put safety measures in place, sure they have, and I’m sure there’s no spread there and that’s true in many places. Remember, there are more people than ever with the virus,” said Farley.
City officials said dramatic action is needed to respond to an exponential growth in cases and hospitalizations.
On Thursday, health officials announced 765 additional confirmed cases of COVID-19 in Philadelphia. That brings the number of confirmed cases to 57,237.
The number of residents who have died from the virus in Philadelphia is 1,945.
How is 2nd wave of COVID-19 impacting local hospitals?
As the second wave of COVID-19 hits the Philadelphia region, doctors and medical professionals discuss how the virus is impacting hospitals.
Grey Lodge Pub in Mayfair closing
The new round of COVID-19 regulations was the final straw for one Philadelphia restaurant. The Grey Lodge Pub in Mayfair is closing its doors for good after 70 years in business. The Lucky Cat Brewing Company, which is a standalone business inside the pub, will remain open.
Philadelphia museums knocked back down by new COVID-19 restrictions
The new restrictions put in place to tackle the surge of COVID-19 cases in Philadelphia are hitting museums in the area hard. After going through a five-month shutdown during the first wave, they are being shut down again, which in some cases, will cause hard economic pain and uncertainty for employees.
National Constitution Center temporarily closes to the public through January 1, 2021
In accordance with health guidelines from the City of Philadelphia in response to COVID-19, the National Constitution Center is temporarily closed to the public through January 1, 2021. The Center offers a range of free online programs and resources for learners of all ages. CLICK HERE to learn more.
Houses of worship in Philly vow to persevere amid new COVID restrictions
The new COVID-19 restrictions in Philadelphia will have a major impact on houses of worship, which for the time being can operate at only 5% capacity. While the Archdiocese of Philadelphia revises its guidance, some churches and synagogues in the city have a variety of innovative plans to carry on through the holidays.
Philadelphia-area stores stock up as new COVID restrictions set
Aprea Therapeutics to Highlight Changing Treatment Paradigm in MDS as well as Development Pipeline Progress at Virtual R&D Day Today
BOSTON, Oct. 30, 2020 (GLOBE NEWSWIRE) — Aprea Therapeutics, Inc. (Nasdaq: APRE), a biopharmaceutical company focused on developing and commercializing novel cancer therapeutics to reactivate mutant tumor suppressor protein, p53, will host a live virtual R&D Day Webinar, with presentations by key opinion leaders in hematology, today from 1:00 – 3:00 pm Eastern Time.
R&D Day Webinar Agenda:
1:00 pm – 2:00 pm:
Introduction and discussion with Drs. David Sallman (Moffitt Cancer Center), Guillermo Garcia-Manero (MD Anderson Cancer Center), and Eyal Attar (Aprea’s Chief Medical Officer) to review current clinical therapy options for TP53 mutant MDS/AML patients and the potential role of eprenetapopt. Discussion with review of Aprea’s Phase 3 Clinical program in MDS to be followed by Q&A.
2:00 pm – 2:15 pm:
Overview of Aprea’s ongoing commercial preparations in front-line MDS by Greg Wessels, Aprea’s Chief Commercial Officer
2:15 pm – 3:00 pm:
Review of Aprea’s hematology and solid tumor clinical pipeline, by Dr. Eyal Attar followed by Q&A and Wrap-up.
Virtual R&D Day Webinar Information
The live webinar will begin at 1:00 pm Eastern Time and conclude at approximately 3:00 pm. Registration is accessible on the Events page of Aprea’s website. Following the webinar, a replay will be available for a limited time on Aprea’s website.
About Aprea Therapeutics
Aprea Therapeutics, Inc., (NASDAQ: APRE) is a biopharmaceutical company headquartered in Boston, Massachusetts with research facilities in Stockholm, Sweden, focused on developing and commercializing novel cancer therapeutics that reactivate the mutant tumor suppressor protein p53. The Company’s lead product candidate is eprenetapopt (APR-246), a small molecule in clinical development for hematologic malignancies, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Eprenetapopt has received Breakthrough Therapy, Orphan Drug and Fast Track designations from the FDA for MDS, and Orphan Drug designation from the European Commission for MDS, AML and ovarian cancer. APR-548, a next-generation small molecule reactivator of mutant p53, is being developed for oral administration. For more information, please visit the company website at www.aprea.com.
The Company may use, and intends to use, its investor relations website at https://ir.aprea.com/ as a means of disclosing material nonpublic information and for complying with its disclosure obligations under Regulation FD.
About p53, eprenetapopt and APR-548
The p53 tumor suppressor gene is the most frequently mutated gene in human cancer, occurring in approximately 50% of all human tumors. These mutations are often associated with resistance to anti-cancer drugs and poor overall survival, representing a major unmet medical need in the treatment of cancer.
Eprenetapopt is a small molecule that has demonstrated reactivation of mutant and inactivated p53 protein – by restoring wild-type p53 conformation and function – and thereby induce programmed cell death in human cancer cells. Pre-clinical anti-tumor activity has been observed with eprenetapopt in a wide variety of solid and hematological cancers, including MDS, AML, and ovarian cancer, among others. Additionally, strong synergy has been seen with both traditional anti-cancer agents, such as chemotherapy, as well as newer mechanism-based anti-cancer drugs and immuno-oncology checkpoint
In today’s top news in retail, fitness startup Moxie launches its platform, Amazon earnings are expected on Thursday (Oct. 29) and grocery giant Kroger said its “Restock Kroger” framework will generate shareholder returns of 8 to 11 percent.
Moxie launched Tuesday (Oct. 27) after spending the summer and fall in beta. Its CEO likes to call it the Airbnb of fitness. More formally, it is a hybrid fitness site for instructors to reach clients, both new and existing. And it’s a site where fitness enthusiasts can find subscriptions for monthly or weekly live classes, all streamed directly on its platform. Subscribers also get access to the video recordings, which can be streamed on Moxie’s site, as well as music clearances, playlists and CRM functionality for the instructors to manage their clients. During the beta phase, Goldberg says there were more than 6,500 classes available, and more than 10,000 individual sessions were live-streamed. The site has also signed up more than 2,000 instructors.
Amazon Earnings Could Produce First $100B Quarter
Amazon reports earnings on Thursday (Oct. 29) and it has an impossible act to follow. With its Q2 earnings reaping every benefit of the pandemic-driven digital-first economy, it set a new standard for exploding past earnings estimates with revenue up 40 percent to $88.9 billion. While it’s a safe bet that Amazon will beat estimates, it won’t come close to the Q2 performance. But as the retail world waits to see what is expected to be a record-setting quarter for Amazon, there are some key indicators to watch. The company has already level set expectations when it said in July that it expects Q3 net sales to come in at between $87 billion and $93 billion, which would be a year-over-year growth rate of between 24 to 33 percent.
Kroger Bullish On Earnings As Supermarket Giant Takes On Digital World
Kroger Co. “has reinvented the company’s business model to deliver consistently strong and attractive total shareholder return,” the company said in a press release on Tuesday (Oct. 27). The Cincinnati-based supermarket giant said its “Restock Kroger” framework will generate shareholder returns of 8 to 11 percent. Restock Kroger is the company’s program to improve shipping, distribution and the links between its online and offline businesses. The company made “several strategic decisions three years ago” to better service its customers, Kroger Chairman and CEO Rodney McMullen said in the release. “We believed customers would continue to move to a seamless shopping platform that combined the best of physical and digital experiences. These choices and investments have positioned Kroger to more effectively respond to the pandemic,” he said.
Fitness is about far more than your 5K time or the visibility of your abdominal muscles. At Men’s Health, we’ve long strived to present a more thoughtful and multi-faceted view of male health and fitness.
In this issue, you’ll find all the workouts, gear reviews and insider training hacks you’ve come to expect from MH, alongside a more holistic take on health, too. With our 10-page special, Black Minds Matter, we continue our commitment to raising awareness of men’s mental health issues in various sectors of society by looking at the way in which our health services have failed black men.
We also have six feelgood workouts to boost your mental energy and pump up your well-being, plus 31 tips for fortifying your heart against life’s stresses. That, and more besides.
Zack George: Britain’s Fittest Man
Zack George reached the zenith of his sport, only to see his dream dissolve. It has been an intense and busy year for the UK’s finest CrossFitter. This is how he found triumph in adversity to become stronger than ever – and why you need to get with the programming.
Fighting for Black Minds
Black British men are four times more likely than white men to be hospitalised for poor mental health, and are less likely to seek help before they reach crisis point. The system in place to support them is broken. How do we fix it?
The Best Eco Toys in Wellness
Minimising your environmental footprint needn’t mean trading in your Nike Zooms for hemp slippers. Brands at the sharp end of performance are investing time and energy intro crafting sustainable products. Here’s our pick of the best.
Stressed out? The body part you need to target in your next workout is the one between your ears. With a little neurological know-how, your training sessions can expel anxiety and add muscle to flagging motivation. Get a lift from these.
New Ways to Pump Up Your Heart
Almost 80% of UK adults struggle with work-related stress, while heart diseases account for more than a quarter of British deaths. That means staying young at heart isn’t just a romantic cliche – it’s a doctor’s order. Our experts have their fingers on the pulse.
Your Daily Bread
Blame bowl food for the demise of the humble sandwich. Thankfully, London’s upper crust is making your staple lunch great again – in flavour and nutritious goodness. Make a meal of it.
Sign up to the Men’s Health newsletter and kickstart your home body plan. Make positive steps to become healthier and mentally strong with all the best fitness, muscle-building and nutrition advice delivered to your inbox.
For effective home workouts, uplifting stories, easy recipes and advice you can trust, subscribe to Men’s Health UK today
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It is no secret that thousands of laboratories around the world use cells derived from a fetus that was aborted decades ago to develop vital medicines.
But it is a contentious topic in the US, where conservatives and anti-abortion activists have long deemed the practice unethical.
The matter is once more under the spotlight after President Donald Trump was treated for Covid-19 using Regeneron’s antibody treatment. The company used aborted fetal cells as part of its testing process.
“It’s becoming annoying,” Andrea Gambotto, a professor at the University of Pittsburgh, said of the controversy.
Gambotto has used a cell line called HEK 293, the same used by Regeneron, as part of his research for 25 years.
“It’d be a crime to ban the use of these cells,” he added. “It never harmed anybody — it was a dead embryo so the cells back then (were used), instead of being discarded, they were used for research.”
The big advantage of these cells, which were developed in the early 1970s, is that they now represent a “gold standard” in the pharmaceutical industry.
If Gambotto — who is leading a Covid-19 vaccine research project himself — one day succeeds, his vaccine can be produced anywhere in the world, thanks to HEK293.
“You can go to India and make a vaccine for all the world,” he said. To those who call for the development of alternatives, he says, “You don’t need to go back 30 years and reinvent the wheel.”
The original cells were transformed and immortalized in January 1973 by a young Canadian postdoc by the name of Frank Graham, who was working at the time in Leiden, the Netherlands in the laboratory of Professor Alex van der Eb.
Normally, a cell has a finite number of divisions, but Graham managed to modify these cells so that they divide ad infinitum.
This was his 293rd experiment, hence the name of the line (HEK stands for “human embryonic kidney cells”).
“Use of fetal tissue was not uncommon in that period,” Graham, a professor emeritus at Canada’s McMaster University who now lives in Italy, told AFP.
“Abortion was illegal in the Netherlands until 1984 except to save the life of the mother. Consequently I have always assumed that the HEK cells used by the Leiden lab must have derived from a therapeutic abortion.”
Vaccine developers like HEK293 because the cells are malleable and transformable into virus mini-factories. To grow viruses, you always need a host cell. It can be a chicken egg, but human cells are preferable in human medicine.
In the case of Covid-19 vaccines, several makers have used HEK293 to generate what are called “viral vectors.”
These are weakened versions of common cold-causing adenoviruses that are loaded with the genetic instructions for human cells to manufacture a surface protein of the coronavirus. This elicits an immune response that the body remembers when it encounters
South Korea is testing tens of thousands of employees of hospitals and nursing homes to prevent COVID-19 outbreaks at live-in facilities
SEOUL, South Korea — South Korea on Monday began testing tens of thousands of employees of hospitals and nursing homes to prevent COVID-19 outbreaks at live-in facilities.
Fifteen of the 76 latest cases reported by the Korea Disease Control and Prevention Agency were from the southern port city of Busan, where more than 70 infections have been linked to a hospital for the elderly.
Health workers have been scrambling to track infections in the Seoul metropolitan area, home to about half of the country’s 51 million people, as the virus spreads in a variety of places, including hospitals, churches, schools and workplaces.
From Monday, they will start a process to test 130,000 workers at hospitals, nursing homes and senior centers in the greater capital area. Officials will also test 30,000 patients who have visited and used these facilities, but will leave out hospitalized patients, who already receive tests when they are admitted.
Officials plan to complete the tests within October and could possibly expand the screening to other regions if needed.
South Korea has confirmed 25,275 cases of coronavirus infection, including 444 deaths from COVID-19.
In other developments around the Asia-Pacific region:
— China’s economic growth accelerated to 4.9% over a year earlier in the latest quarter as a shaky recovery from the coronavirus pandemic gathered strength. China, where virus outbreaks began in December, became the first major economy to return to growth with a 3.2% expansion in the quarter ending in June. Output contracted 6.8% in the first quarter. The ruling Communist Party began easing anti-disease controls and reopening factories, shops and offices in March after declaring the virus under control but has kept monitoring and some travel controls in place.