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Dioxane levels rise; Michigan Medicine further restricts visitors; Small Business Saturday in A2

Happy Friday!

I hope you had a nice Thanksgiving, even though it likely looked different this year. Today is Black Friday, and although it’s known for great deals to be had at big-box stores, a lesser-known day is Small Business Saturday. Now more than ever, local businesses need support — especially as the pandemic and cold weather restrict operations.

Need some ideas? Main Street Ann Arbor just released its annual shopping guide. Here’s another guide that highlights businesses that are women- and minority-owned. Meanwhile, this gift guide focuses on local food and drink producers. Sarah has also spent the past several months speaking with local business owners and highlighting them for her Small Business Saturday series. Don’t see your favorite business on the list? Submit it here.

Have a great long weekend.

– Meredith (@meredith_A4)

What’s been happening:

⛔️ Michigan Medicine announced this week that no visitors are allowed for adult patients as COVID-19 cases spike across the state. There are some exceptions to the new policy, which took effect on Wednesday. (A4)

🚰 Recent tests from water samples taken in October in the West Park area reveal a spike in Dioxane levels, concerning local officials. (MLive)

🚶‍♀️ The city of Ann Arbor celebrated the grand opening of the Allen Creek Railroad Berm Project this week virtually. (A4)

🚲 Have a look at the new downtown protected bikeway on First Street. (MLive)

🛤 The long-awaited passenger train service from Ann Arbor to Traverse City — known as A2TC — has put test rides slated for 2021 on hold due to the pandemic. (Detroit Free Press)

🎓 A senior at the University of Michigan became the school’s 29th Rhodes Scholar since the awards were established in 1902. (A4)

💻 Toyota and Cisco have partnered to install free Wi-Fi at public sites in the region, including in Ann Arbor and Ypsilanti. (A4)

Good to know:

🌯 Vegan Kerrytown joint Detroit Street Filling Station expanded into the space next door. The owner said it could become a private dining space or intimate music venue. (A4)

🍪 Have kids ages 8 and up? Love holiday cookies? This local cooking school for kids will be hosting holiday cookie classes online for the whole family. (A4)

🎅 Santa’s Mailbox will return to Main St. this year. From Nov. 28-Dec. 14, write a letter to Santa with a return address and you will receive a response. (A4)

🤝 Tuesday is Giving Tuesday. The annual Rockin’ for the Hungry fund drive by Food Gatherers, ann arbor’s 107one and Kroger will kick off virtually on Tuesday, as will Ann Arbor Summer Festival’s campaign which will feature free performances by Michigan-based artists throughout the day. (A4)

Feature interview of the week:

“We had to pivot to something that is ironic for us, because the whole gist of Literati is that it is a community bookstore that

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dentist

Allison Reed is happy to be a small town dentist in Coshocton

COSHOCTON – Dr. Allison Reed of Reed Family Dental has always wanted to set up shop in a small town and Coshocton is one where she has connections.



a man and a woman sitting in a chair: Dr. Allison Reed of Reed Family Dental joined Dr. Todd Salmans' about a year and a half ago and took over the practice upon his retirement on Oct. 1. She grew up in Johnstown, but has family in Coshocton and always wanted to practice in a small town.


© Leonard Hayhurst/Tribune
Dr. Allison Reed of Reed Family Dental joined Dr. Todd Salmans’ about a year and a half ago and took over the practice upon his retirement on Oct. 1. She grew up in Johnstown, but has family in Coshocton and always wanted to practice in a small town.

Dr. Todd Salmans retired Oct. 1 after nearly 25 years of dental practice. Reed came into his firm about a year and a half ago straight from dental school with the intentions of eventually taking over.

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Salmans sent a letter to patients thanking them for their loyalty and trust.

“Long before I decided to retire, I was searching for a dentist who shares in my same ideas of caring for patients like family,” he said in the letter. “(Reed) has proven to be a caring, calm and meticulous dentist and I am impressed with her ability to treat patients with confidence and competence.”

Reed has kept all of Salman’s nine-person staff and more than 4,300 patients. She’s not looking to bring in another dentist right now, and said the practice is growing as other local dentists have recently retired or sold out to corporate dentistry chains.

“We have a ton of people coming to us, because they don’t like that corporate setting. It’s just different. … They like we’re still family owned.”

Salmans was directed to Reed by her uncle Chad Johnson, who serves on city council with Salmans’ wife, Jackie. Jackie was also Todd’s office manager and, in similar fashion, Reed’s husband, Evan, is taking on that role for her. He also works as an ICU nurse at Ohio University Wexner Medical Center in Columbus. The couple married in 2018 and moved to Coshocton in early September.



a man and woman posing for a picture: Evan Reed and Dr. Allison Reed of Reed Family Dental. Evan works as a nurse in Columbus, but is also serving as the office manager for his wife. Allison recently took over the dental practice of Todd Salmans after his retirement.


© Leonard Hayhurst/Tribune
Evan Reed and Dr. Allison Reed of Reed Family Dental. Evan works as a nurse in Columbus, but is also serving as the office manager for his wife. Allison recently took over the dental practice of Todd Salmans after his retirement.

Reed said Salmans was a real mentor to her and taught her a lot about the practical side of dentistry you don’t learn in a classroom. On several days, he let her do most of the work and he would monitored. Reed appreciated the faith he had in her.

“He taught me how to figure out my timing with talking to patients, getting procedures done, getting things done fast and multitasking,” Reed said. “I did a little bit of it in school, we worked in Medicaid offices, but it’s not the same situation out here. He taught me more about specific procedures.”

Reed attended Wright State University for her undergraduate degree and spent a few years teaching math and biomechanics at the college. Her interests turned to dentistry when it was suggested by her childhood dental hygienist.

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health

Oregon Decriminalizes Small Amounts Of Heroin, Meth, Cocaine, Legalizes Magic Mushrooms For Therapy

Topline

Oregon voters on Tuesday approved the most progressive drug policy in the U.S. with a pair of ballot measures that legalize psilocybin mushrooms for mental health treatment, decriminalize small amounts of street drugs and establish a drug treatment program funded by marijuana tax dollars.

Key Facts

Oregon voters passed both Measure 109 and Measure 110, which both drastically alter the state’s drug policy as advocates aim to combat addiction using public health tools instead of incarceration.

Measure 109 creates a program for licensed professionals to administer magic mushrooms to help with depression, anxiety, and addiction—but people would only be allowed to consume psilocybin at regulated treatment centers.

Measure 110 decriminalizes small amounts of cocaine, meth, psilocybin mushrooms, LSD, MDMA, methadone and oxycodone for both adults and juveniles and instead imposes a maximum $100 fine for possession. 

The initiative overhauls the state’s addiction treatment program by creating 16 “health assessment centers” from marijuana tax revenue; if someone is caught with small amounts of a controlled substance, they can either pay the $100 fine or get the fee waived by taking a free health assessment at a treatment center.

At treatment centers, clients will be assigned individual case managers for screening and referral services, but only if the client “indicates a desire” to address any identified substance abuse issues, according to the text of the measure.

Key Background

Advocates have been pushing for drug reform in recent years, arguing that users need treatment instead of jail time, especially because there are large racial disparities in who gets punished for drug crimes. The ACLU, the Drug Policy Alliance and Facebook CEO Mark Zuckerberg along with his wife Priscilla Chan, all donated money to pass Measure 110. It’s also endorsed by the Oregon Nurses Association and the Oregon Public Health Association and the NAACP Portland.

Crucial Quote

“Instead of arresting and jailing people for possessing small amounts of drugs, Measure 110 would shift to a health-based approach, and use marijuana tax revenue to pay for more addiction and other health services. Measure 110 will save money and save lives,” the Drug Policy Alliance said.

Chief Critics

Some healthcare providers say the measure doesn’t do enough to ensure those addicted to drugs get treatment, and would divert marijuana tax revenue currently used for K-12 schools and existing addiction treatment programs. “It would only require the creation of 16 centers to provide screenings and referrals. It does not require the creation of a single new treatment bed,” Paul C. Coelho, Salem Health Pain Clinic’s medical director, wrote in a Statesman Journal op-ed. “Referrals are not treatment. Screenings are not access.”

Critics, including the Oregon Association Chiefs of Police, also say it would be dangerous for children. “The measure would make it so a 15-year-old can get caught with a pocket full of meth, and the only consequences

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health

Outbreak Fueled By Small Get-Togethers, Puts LA In Tough Spot

LOS ANGELES, CA — At least a third of the people recently infected with the coronavirus in Los Angeles admitted to attending small get togethers while about 10 percent admitted to attending larger gatherings, according to ongoing USC study. More than half of those recently infected reported being close contact with people outside their household.

The study also found that roughly one-third of recently infected respondents reported visiting another person’s home in the previous seven days, while one- third said they had visitors at their own home. About 10% said they had attended a gathering of 10 or more people in the past week.

The study is among the mounting evidence that the outbreak is on the rise again in large part because of small gatherings and parties in defiance of health orders. The damage such gatherings can do during the pandemic is staggering.

“I know this sounds like a small number, but if 10% of L.A. residents attend gatherings, this translates to 1 million people gathering with others not in their household,”Los Angeles County’s Public Health Director Barbara Ferrer said. “And if we assume that 2% of people can be infected, we could possibly have 20,000 people capable of infecting others who are milling about at these gatherings each week.”

The findings should serve as a warning that the virus can as easily spread among friends and family as it can among strangers in public places. Los Angeles County’s public health director warned Monday of an already worsening COVID-19 situation becoming even more dire during the upcoming holiday season without rapid behavioral changes.

Patients who have become infected with the coronavirus show steady increases in interactions with people outside their own households,Barbara Ferrer said . The ongoing USC study found that for the week ending Oct. 20, 57% of survey respondents reported being in close contact with someone they don’t live with in the previous seven days.

Ferrer said the USC data, combined with information collected during contact-tracing interviews with virus patients, shows “there’s ample evidence that gatherings are increasing and are one of the drivers of the increases in cases in L.A. County.”

And with Thanksgiving just weeks away, Ferrer said concern is mounting that the holidays could make things worse.

“With our case numbers already on the rise, we are concerned about the upcoming months,” Ferrer said. “Holiday gatherings and cooler weather, when people are more likely to gather indoors, are perfect conditions for spreading COVID-19.”

Ferrer announced another 1,406 coronavirus cases on Monday — a day that is typically marked by relatively low daily case numbers due to reporting lags from the weekend. She noted that the county has reported almost 3,000 new cases over the last two days, a time of week when numbers are always lower than the rest of the week.

“So if that trend holds true, then we’re going to see higher numbers for the rest of this week,” she said. “And that would in fact not only create a

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fitness

Capacity limitations threaten the survival of Tucson’s small fitness businesses | Business News

MAKING IT WORK

Concerned about whether their businesses can survive under the current capacity limitations, some owners have turned to outdoor classes, which are not limited by ADHS requirements as long as physical distancing is possible.

Soleil Chiquette, the owner of Let’s Sweat, opted to offer only outdoor classes after the second COVID-19 shutdown inhibited gyms and studios from operating in June.

Chiquette knew her customers weren’t comfortable being back inside, so she decided to offer spin and strength classes out on the Let’s Sweat patio, 439 N. Sixth Ave., and at Catalina Park instead. Let’s Sweat’s outdoor classes are popular among their clients, and they have allowed Chiquette to stay above water.

The same can be said for Lucas, the owner of Session Yoga. Lucas owns two studios at 123 S. Eastbourne Ave. and 1135 N. Jefferson Ave. One of her spaces is a strictly indoor studio that offers hot yoga classes, and the other has both indoor and outdoor options.

Lucas has been able to consistently offer outdoor classes, which has helped her keep her studios afloat.

“Luckily, I was able to continue with the outdoor yoga, so that sustained us from not closing permanently. Without that, I don’t think we would have made it,” Lucas said.

Some studio owners have been unable to transition to outdoor classes because they rely on an indoor environment to create a specific atmosphere.

At Tucson Yoga Sol, a hot yoga studio in northwest Tucson, this is the case. Instructors manipulate heaters to facilitate Bikram yoga and hot Pilates classes. The owner, Diane Van Maren, is unsure if she will be able to keep her business up and running if the current restrictions remain in place.

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health

In A Small Pennsylvania City, A Mental Crisis Call To 911 Turns Tragic : Shots

Rulennis Munoz (center right) outside Lancaster Courthouse Oct. 14, after learning that the police officer who fatally shot her brother had been cleared of criminal wrongdoing by the Lancaster County District Attorney. Her mother, Miguelina Peña, and her attorney Michael Perna (far right) stood by.

Brett Sholtis/WITF


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Brett Sholtis/WITF

Rulennis Muñoz remembers the phone ringing on Sept. 13. Her mother was calling from the car, frustrated. Rulennis could also hear her brother Ricardo shouting in the background. Her mom told her that Ricardo, who was 27, wouldn’t take his medication. He had been diagnosed with paranoid schizophrenia five years earlier.

Ricardo lived with his mother in Lancaster, Pa., but earlier that day he had been over at Rulennis’ house across town. Rulennis remembers that her brother had been having what she calls “an episode” that morning. Ricardo had become agitated because his phone charger was missing. When she found it for him, he insisted it wasn’t the same one.

Rulennis knew that her brother was in crisis and that he needed psychiatric care. But she also knew from experience that there were few emergency resources available for Ricardo unless a judge deemed him a threat to himself or others.

After talking with her mom, Rulennis called a county crisis intervention line to see if Ricardo could be committed for inpatient care. It was Sunday afternoon. The crisis worker told her to call the police to see if the officers could petition a judge to force Ricardo to go to the hospital for psychiatric treatment, in what’s called an involuntary commitment. Reluctant to call 911, and wanting more information, Rulennis dialed the non-emergency police number.

Meanwhile, her mother, Miguelina Peña, was back in her own neighborhood. Her other daughter, Deborah, lived only a few doors down. Peña started telling Deborah what was going on. Ricardo was becoming aggressive; he had punched the inside of the car. Back on their block, he was still yelling and upset, and couldn’t be calmed. Deborah called 911 to get help for Ricardo. She didn’t know that her sister was trying the non-emergency line.

The problems and perils of calling 911 for help with mental health

A recording and transcript of the 911 call show that the dispatcher gave Deborah three options: police, fire or ambulance. Deborah wasn’t sure, so she said “police.” Then she went on to explain that Ricardo was being aggressive, had a mental illness and needed to go to the hospital.

Meanwhile, Ricardo had moved on, walking up the street to where he and his mother lived. When the dispatcher questioned Deborah further, she also mentioned that Ricardo was trying “to break into” his mom’s house. She didn’t mention that Ricardo also lived in that house. She did mention that her mother “was afraid” to go back home with him.

The Muñoz family has since emphasized that Ricardo was never a threat to them. However, by the time police got the message, they believed they were responding to

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health

How a Small Biotech Survives Amid Looming Antibiotic Crisis

What if the drug that could save you or a loved one from a case of drug-resistant bacterial pneumonia was invented, approved and for sale, but you couldn’t get it?

What if there were several new approved drugs that could fight against a growing threat of aggressive bacterial infections, but the companies making them either have gone bankrupt or they’re struggling to get doctors to prescribe them?

It couldn’t happen, right? Think again.

“Bankruptcy is destroying antibiotics much faster than resistance,” said Kevin Outterson, a Boston University health and disability law professor, in an email to TheStreet.

In the U.S. and around the globe, creating new antibiotics is becoming failing business model — and it’s hurting health care as much as the drugs’ makers. Almost half of the Food and Drug Administration-approved antibiotics in the last decade have suffered an “economic wipe-out” in the past two years, said Outterson, who’s followed the industry for nearly two decades.

The obstacles are many: A broken marketplace for new antibiotics, unrealistic drug pricing expectations and a pervasive belief that new artillery against bacteria should be held onto tightly instead of firing on the front lines.

One outlier is Boston-based Paratek  (PRTK) – Get Report, a biotech whose main product is Nuzyra, a tetracycline-class antibiotic that’s considered an upgraded weapon in the battle against bacterial pneumonia and acute skin infections. It’s surviving, but struggling to get its drug to patients. Its stock currently trades on Nasdaq for around five bucks — a fraction of its value years ago — and its market cap is just $224.67 million.

Outterson says the industry’s problem is so bad that only two of the new small public companies with FDA-approved antibiotics have avoided bankruptcy or getting bought up at fire-sale prices. One is Paratek and the other is a biotech called Nabriva  (NBRV) – Get Report, whose main product is Lefamulin, a partially synthetic compound that prevents bacteria from growing.

“The companies behind five other antibiotics have gone through either bankruptcy or a sale at a steep discount,” said Outterson. 

The cost of developing new antibiotic drugs can get close to $1.5 billion overall, according to a 2017 paper funded by AstraZeneca. Yearly revenues for the new products, however, are a crumb of that amount.

“With antibiotics, people still believe that you should be getting them for a buck,” Dr. Evan Loh, chief executive of Paratek, told TheStreet during a recent phone interview. But, he said, “with small biotechs like Paratek now accounting for about 95% of the innovation in antibiotics, we just don’t have the ability, nor are we able, to sell our products at a loss.”

The pricing for antibiotics, he and other industry experts say, is far different from, say, drugs used for cancer treatment. 

“On day-one, with a new oncology product that extends someone’s life for six weeks – but that is not life-saving like antibiotics are – you can charge $50,000 or $60,000 and doctors and

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health

Coronavirus bears down on a small Montana town

Whitefish city council member Steve Qunell urged restrictions to curb spread of the coronavirus.
Whitefish City Council member Steve Qunell urged restrictions to curb the spread of the coronavirus. (Richard Read / Los Angeles Times)

When Steve Qunell won a seat on the City Council last year in this town of 8,000, he figured he’d be dealing with potholes and affordable housing.

Instead, he finds himself at the center of a raging debate over how to fight the coronavirus, which is surging in Montana like never before.

The state’s governor, Steve Bullock, a Democrat who is in the final stretch of a tight U.S. Senate race and has been reluctant to impose restrictions that could hurt his campaign, called on the hardest-hit counties to consider shutting bars and enforcing a statewide mask mandate.

There was little appetite for that in conservative Flathead County, where the health board has been dominated by an outspoken doctor who argues that the pandemic is a hoax.

That left the Whitefish City Council.

“We are the last line of defense,” Qunell, a 49-year-old high school social studies teacher, told his fellow council members during an online public meeting this week. “Are we going to lead? Or are we just going to follow the nonbelievers in the county?”

Places like Whitefish once could afford to view the pandemic as a distant big-city problem. Through mid-September, sparsely populated Montana had a death toll of 140.

But that figure has doubled over the last five weeks as a new wave of infections sweeps the country. More than 85,000 cases were reported nationwide Friday, the most in a single day since the pandemic began.

The worst outbreaks are in the rural Midwest and Rocky Mountains. With 4,693 new cases over the last week, Montana had the country’s third-highest infection rate, trailing only the Dakotas.

The rise in Montana has overwhelmed efforts to conduct contact tracing and strained health systems across the state.

And as events in Whitefish show, efforts to stem exponential increases are pushing up against a culture that prides itself on rugged independence and freedom from government rules.

Early in the pandemic, Whitefish, a gateway to ski areas and Glacier National Park, moved more decisively than many other communities to contain the virus.

Whitefish Mountain Resort looms above Whitefish, Mont., gateway to Glacier National Park.
Whitefish Mountain Resort looms above Whitefish, Mont., gateway to Glacier National Park. (Richard Read / Los Angeles Times)

Last spring, the City Council ordered hotels and short-term rental properties to take in only essential workers — a requirement that remained in place until the end of May.

Whitefish was also one of the first cities in Montana to make people wear masks — though the governor soon issued a mandate statewide.

Still, from the beginning, there was strong local opposition to such restrictions.

Leading the resistance was Dr. Annie Bukacek, a 62-year-old internist known for her far-right views and opposition to vaccination.

Flathead County commissioners appointed her to the county health board last December after dismissing two other doctors with more public health experience — changes the commissioners said were meant to increase the diversity of views.

Bukacek

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medicine

Cyanobacteria: Small candidates as great hopes for medicine and biotechnology

IMAGE

IMAGE: The team headed by Dr Paul D’Agostino will sequence 40 symbiotic and rare terrestrial cyanobacteria for the production of new active agents and to explore the potential for applications in…
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Credit: Paul D’Agostino

In order to unlock the genetic potential of unusual cyanobacteria for the production of new active agents and to explore the potential for applications in biotechnology, the team headed by Dr Paul D’Agostino has been awarded a competitive whole-genome sequencing grant from the Joint Genome Institute (JGI) in the USA.

An ever-growing global population, an increasing standard of living and environmental challenges such as anthropogenic climate change, ocean pollution, the declining availability of arable land and dwindling fossil resources – these are today’s global challenges. Therefore, the German Federal Ministry of Education and Research has dedicated the Science Year 2020/21 to the topic Bioeconomy with the aim of meeting these challenges with little heroes. The “stars” of bioeconomy are proteins, algae, microorganisms, and other tiny creatures with great impact.

At the Chair of Technical Biochemistry at TU Dresden, the researchers will now focus on some of the oldest of such little superheroes: cyanobacteria. There are about 2000 species of cyanobacteria and many of these species have been poorly researched. Dr Paul D’Agostino, Professor Tobias Gulder and their team – including cooperation partners Michelle Gehringer (TU Kaiserslautern), Michael Lakatos and Patrick Jung (both Hochschule Kaiserslautern) – hope that unusual cyanobacteria will yield promising results and make an innovative contribution to bioeconomy.

“Microorganisms produce valuable organic molecules with great potential for many applications. It is important to know that unusual organisms often also produce novel bioactive agents. The discovery of such new, bioactive molecules is essential if one thinks, for example, of new medical challenges such as the coronavirus and the progressive development of resistance to established active agents. Within the scope of this project, we therefore want to investigate the genetic potential of very unusual cyanobacteria for the production of innovative active pharmaceutical ingredients,” explains Gulder.

As a first step, the team will predict the potential of natural compounds by sequencing the genomes and subsequent bioinformatic analysis.

The results can then be translated into the targeted discovery of new molecules using modern methods of synthetic biology and biotechnology. As a final step, the project will focus on the production and characterization of these natural compounds and on the application of the enzymes producing these compounds as biocatalysts for the development of sustainable chemical processes.

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Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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medicine

Small candidates as great hopes for medicine and biotechnology

Cyanobacteria: Small Candidates as Great Hopes for Medicine and Biotechnology
The team headed by Dr Paul D’Agostino will sequence 40 symbiotic and rare terrestrial cyanobacteria for the production of new active agents and to explore the potential for applications in biotechnology. Credit: Paul D’Agostino

An ever-growing global population, an increasing standard of living and environmental challenges such as anthropogenic climate change, ocean pollution, the declining availability of arable land and dwindling fossil resources—these are today’s global challenges. Therefore, the German Federal Ministry of Education and Research has dedicated the Science Year 2020/21 to the topic Bioeconomy with the aim of meeting these challenges with little heroes. The ‘stars’ of bioeconomy are proteins, algae, microorganisms, and other tiny creatures with great impact.


At the Chair of Technical Biochemistry at TU Dresden, the researchers will now focus on some of the oldest of such little superheroes: cyanobacteria. There are about 2000 species of cyanobacteria and many of these species have been poorly researched. Dr. Paul D’Agostino, Professor Tobias Gulder and their team—including cooperation partners Michelle Gehringer (TU Kaiserslautern), Michael Lakatos and Patrick Jung (both Hochschule Kaiserslautern) – hope that unusual cyanobacteria will yield promising results and make an innovative contribution to bioeconomy.

“Microorganisms produce valuable organic molecules with great potential for many applications. It is important to know that unusual organisms often also produce novel bioactive agents. The discovery of such new, bioactive molecules is essential if one thinks, for example, of new medical challenges such as the coronavirus and the progressive development of resistance to established active agents. Within the scope of this project, we therefore want to investigate the genetic potential of very unusual cyanobacteria for the production of innovative active pharmaceutical ingredients,” explains Gulder.

As a first step, the team will predict the potential of natural compounds by sequencing the genomes and subsequent bioinformatic analysis. The results can then be translated into the targeted discovery of new molecules using modern methods of synthetic biology and biotechnology. As a final step, the project will focus on the production and characterization of these natural compounds and on the application of the enzymes producing these compounds as biocatalysts for the development of sustainable chemical processes.


Artificial cyanobacterial biofilm can sustain green ethylene production for over a month


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