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medicine

Promising new data for Ionis’ antisense medicine targeting PCSK9 presented at American Heart Association (AHA) Scientific Sessions 2020

CARLSBAD, Calif., Nov. 13, 2020 /PRNewswire/ — Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) announced today that new data for ION449, an investigational antisense medicine designed to reduce plasma levels of proprotein convertase subtilisin/kexin type 9, or PCSK9, were presented today at the American Heart Association (AHA) Scientific Sessions. PCSK9 is integrally involved in the regulation of LDL-cholesterol (LDL-C). Genetic studies have shown that individuals with life-long reduction of LDL-C due to reduced function of PCSK9 have substantially reduced risk of cardiovascular disease.

(PRNewsfoto/Ionis Pharmaceuticals, Inc.)

ION449, also known as AZD8233 for subcutaneous administration and AZD6615 for oral administration, is being developed as part of a collaboration between Ionis and the biopharmaceutical company AstraZeneca. ION449 incorporates Ionis’ advanced Generation 2.5 and LIgand Conjugated Antisense, or LICA, technology. In a Phase 1 study, single subcutaneous doses of ION449 demonstrated dose-dependent reductions in circulating plasma PCSK9 protein and LDL-C levels of up to >90 percent and up to ~70 percent, respectively, in humans with a baseline LDL-C between 100 and 190 mg/dL.Doses of 4, 12, 20, 30, 60, 90 and 120 mg were evaluated. The single 90 mg dose was the minimum dose required to achieve maximum reduction in PCSK9 and LDL-C. ION449 was observed to be safe and well tolerated at all dose levels.

In addition, the feasibility of oral administration of ION449 was established in three in vivo studies:

  • A study in rats demonstrated liver bioavailability of 5 percent with ION449 following intrajejunal administration, mimicking oral administration of tablets not feasible in rodents.
  • A study in dogs demonstrated liver bioavailability of 7 percent following ION449 oral tablet administration for 28 days.
  • A study in healthy monkeys found repeated oral administration of ION449 tablets for 14 days resulted in LDL-cholesterol reductions of 45–50 percent.

An oral formulation of ION449 is currently being evaluated in a Phase 1 study in healthy volunteers.

“Even with existing treatments, cardiovascular disease remains the leading cause of death worldwide, affecting tens of millions of people. Additional treatments are clearly needed for patients still at risk. The data from these studies are very encouraging and demonstrate the best-in-class potential of ION449 for lowering LDL-C via PCSK9 reduction for the treatment of patients with high cholesterol who are at risk of cardiovascular disease,” said Brett P. Monia, Ph.D., chief executive officer at Ionis.

The full poster presentations, “Single Dose Safety, Pharmacokinetics, and Pharmacodynamics of a Potent PCSK9 Synthesis Inhibitor, AZD8233, in Subjects With Elevated LDL Cholesterol” (Poster #MP515) and “An Oral Antisense Oligonucleotide for PCSK9 Inhibition in Humans” (Poster #P244) are available to view on the AHA Scientific Sessions website.

Ionis’ collaboration with AstraZeneca focuses on leveraging Ionis’ pioneering antisense technology to discover and develop antisense therapies and AstraZeneca’s expertise in drug development and commercialization. In addition to cardiovascular programs, the companies are also collaborating to discover and develop antisense drugs to treat cancer, metabolic and other diseases.

About Ionis Pharmaceuticals, Inc.
As the leader in RNA-targeted drug discovery and development, Ionis has created an

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fitness

UAE’s Aster offers free fitness sessions, giveaways, discounted health check-ups

Dubai: Free fitness sessions, rewards, giveaways and discounted health check-ups on select days — a UAE-based health care group is going all out to promote fitness, health and wellbeing as the Dubai Fitness Challenge 2020 gets underway.

The move comes in the wake of the health care group – Aster Hospitals & Clinics UAE – becoming the official Hospitals and Clinics partner of the Dubai Fitness Challenge 2020.

The group, which has a network of four hospitals and 90 clinics in the country, said it is supporting the vision of Sheikh Hamdan Bin Mohammed bin Rashid Al Maktoum, Dubai Crown Prince and Chairman of The Executive Council of Dubai, to boost a healthy lifestyle through a simple task of performing 30 minutes of activity for 30 days straight, and thereby tackle the rising levels of obesity.

As official partner of DFC 2020, Aster said it will put all hands-on-deck to help residents do their part towards an active lifestyle. In order to achieve this objective, the group has launched a #LiveBetterwithAster campaign for residents of Dubai that will consist of free sessions with fitness experts and health checks at the Fitness Villages in Quranic Park and Kite Beach. In addition, residents can work on their own fitness and get rewarded for it through participation in contests and giveaways where they can win gift hampers and vouchers. Residents will also be able to avail special discounts in health check-ups, between October 30 and November 28, and avail them at any of the Aster hospitals and clinics in UAE before December 31, 2020.

Dr Sherbaz Bichu, CEO of Aster Hospitals & Clinics UAE, said, “As leading healthcare providers in the region, the objectives of the Dubai Fitness Challenge work in symbiosis with our long-term goals to improve quality of life of the residents of the country. As official partners, Aster Hospitals & Clinics will be working on various initiatives to help motivate residents of Dubai to inculcate fitness regimes as part of their daily lifestyle. We have also launched several initiatives to motivate our own employees to participate in this campaign.”

Aster has also launched the Aster Wellbeing Programme, a group-wide campaign to drive employee wellbeing through individual and group initiatives during the month of November. Various fitness sessions are being conducted in various Aster hospital and clinic units for their employees, as well as employees based in Aster units across seven countries. Fitness challenges and activities have also been introduced for employees to participate in and support their own overall wellbeing.

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fitness

2,000 free sessions on offer under month long Dubai Fitness Challenge starting October 30

Hamdan in DFC
Sheikh Hamdan participating in the Dubai Fitness Challenge 2019. Sheikh Hamdan on Tuesday challenges each and every one in the city to embrace fitness journey and make a difference in life.
Image Credit: instagram.com/Faz3

Dubai: Dubai Fitness Challenge (DFC) is set to return from October 30 to 28 November to inspire residents and visitors to pursue an active lifestyle by committing to 30 minutes of activity daily for 30 days.

Launched in 2017 by Shaikh Hamdan Bin Mohammad Bin Rashid Al Maktoum, Crown Prince of Dubai and Chairman of The Executive Council of Dubai, the fourth edition of the challenge will feature a calendar of virtual and physical events including sports, health and wellness activities.

Fitness for all age groups

DFC has been designed to help people of all ages, abilities and fitness levels improve their health and social well-being and experience a diverse range of physical and virtual fitness, sports and exercise programmes. Public health and safety will remain paramount throughout DFC, with all physical events strictly following preventive regulations outlined by the Dubai government, including social distancing, safety precautions and hygiene and sanitisation guidelines against the COVID-19 pandemic.

Transform

Inviting members of the Dubai community as well as government entities, businesses and schools to take on the Dubai Fitness Challenge 2020, Shaikh Hamdan said: “The return of Dubai Fitness Challenge is a testament to the emirate’s resilience and its commitment to rebuild a stronger and happier society by embracing the benefits of fitness and wellness habits. When we create the right habits and make them a part of our lives, we have the opportunity to truly transform ourselves.

“Dubai is a city that recognises the importance of physical, mental and social well-being, and constantly strives to provide everyone opportunities for an active lifestyle. All it takes for you to succeed is an unyielding pledge to enjoy 30 minutes of activity for 30 days. I challenge each and every one of you to embrace your fitness journey and make a difference in your life. Together, let’s make the UAE the most active country in the world.”

At-home sessions

DFC 2020 will have a special focus on at-home sessions with the return of its ‘Find Your 30’ virtual content hub on its website. The free-to-access, one-stop destination will host a wide range of fitness content for all ages and abilities, while providing inspiration and trusted information for users to craft their individualised fitness programmes. Participants can explore workout videos, 30-day exercise programmes, discipline challenges, healthy recipes, health and wellness articles, vlogs, educational videos for children, and much more from leading experts in the fitness and health industry. The hub will also provide easy access to DFC’s events and sessions, ensuring participants can navigate their personal fitness journeys both during the Challenge and beyond.

The hub will also feature ‘City is a Gym’, a virtual map spanning 30 locations across the city where individuals can exercise for free without any equipment. Upon arrival at each location, participants will be able to

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