I hope you had a nice Thanksgiving, even though it likely looked different this year. Today is Black Friday, and although it’s known for great deals to be had at big-box stores, a lesser-known day is Small Business Saturday. Now more than ever, local businesses need support — especially as the pandemic and cold weather restrict operations.
Need some ideas? Main Street Ann Arbor just released its annual shopping guide. Here’s another guide that highlights businesses that are women- and minority-owned. Meanwhile, this gift guide focuses on local food and drink producers. Sarah has also spent the past several months speaking with local business owners and highlighting them for her Small Business Saturday series. Don’t see your favorite business on the list? Submit it here.
Have a great long weekend.
– Meredith (@meredith_A4)
What’s been happening:
⛔️ Michigan Medicine announced this week that no visitors are allowed for adult patients as COVID-19 cases spike across the state. There are some exceptions to the new policy, which took effect on Wednesday. (A4)
🚰 Recent tests from water samples taken in October in the West Park area reveal a spike in Dioxane levels, concerning local officials. (MLive)
🚶♀️ The city of Ann Arbor celebrated the grand opening of the Allen Creek Railroad Berm Project this week virtually. (A4)
🚲 Have a look at the new downtown protected bikeway on First Street. (MLive)
🛤 The long-awaited passenger train service from Ann Arbor to Traverse City — known as A2TC — has put test rides slated for 2021 on hold due to the pandemic. (Detroit Free Press)
🎓 A senior at the University of Michigan became the school’s 29th Rhodes Scholar since the awards were established in 1902. (A4)
💻 Toyota and Cisco have partnered to install free Wi-Fi at public sites in the region, including in Ann Arbor and Ypsilanti. (A4)
Good to know:
🌯 Vegan Kerrytown joint Detroit Street Filling Station expanded into the space next door. The owner said it could become a private dining space or intimate music venue. (A4)
🍪 Have kids ages 8 and up? Love holiday cookies? This local cooking school for kids will be hosting holiday cookie classes online for the whole family. (A4)
🎅 Santa’s Mailbox will return to Main St. this year. From Nov. 28-Dec. 14, write a letter to Santa with a return address and you will receive a response. (A4)
🤝 Tuesday is Giving Tuesday. The annual Rockin’ for the Hungry fund drive by Food Gatherers, ann arbor’s 107one and Kroger will kick off virtually on Tuesday, as will Ann Arbor Summer Festival’s campaign which will feature free performances by Michigan-based artists throughout the day. (A4)
Feature interview of the week:
“We had to pivot to something that is ironic for us, because the whole gist of Literati is that it is a community bookstore that
Traditional Chinese Medicine Market is Driven by Rise in Popularity among Major Population from all Across the World
Global Traditional Chinese Medicine Market: Snapshot
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- Mayo Clinic
- YinOvaCenter and WOTCM
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ANN ARBOR, MI – No visitors will be allowed with adult patients in Michigan Medicine hospitals, except when medically necessary, as the health system tries to minimize COVID-19 spread.
Michigan Medicine announced the changes that will go into effect on Wednesday, Nov. 25. Information on exceptions, including end-of-life care, labor and delivery and other situations, can be found here.
“COVID-19 transmission rates continue to climb in the community. Our top priority is the safety of our patients and staff, and to minimize the spread of disease, we need to take this additional step,” said Laraine Washer, M.D., Michigan Medicine’s medical director of infection prevention and epidemiology, in a news release.
“We know this is difficult for our patients and their families and friends. But we need to continue to keep our Michigan Medicine facilities safe for all of our patients.”
The latest visitor limitations come in addition to restrictions the health system previously announced, including not allowing visitors with adult emergency department patients; a two-visitor limit for pediatric patients and mask requirement at C.S. Mott Children’s Hospital; and no visitor rule for adult patients at Michigan Medicine clinics, unless the patient has a cognitive or physical impairment that requires assistance.
As of Nov. 23, Michigan Medicine reported 103 patients currently admitted that tested positive for COVID-19 – the highest number since late April.
Washer encouraged people to stay home this Thanksgiving and avoid gatherings with those outside your household.
“The best advice to limit risk is to continue to avoid gathering with people outside your household even if it is Thanksgiving. If you are reporting to work, don’t have potlucks or share meals in close proximity with your co-workers: you can’t eat without taking off your mask, and that brief period of not wearing a mask could be enough to open the door to disease spread,” Washer said.
Wear masks, Michigan Medicine leaders tell public as hospitalizations surge
Michigan coronavirus outbreaks increase 45% in 2 weeks
Exhausted in a ‘nightmare’: A look inside a Michigan hospital COVID unit
Editas Medicine, Inc. EDIT delivered earnings of 12 cents per share in the third quarter of 2020, reversing the year-ago quarter’s loss of 66 cents. The Zacks Consensus Estimate was of a loss of 66 cents per share.
Collaboration, and other research and development revenues comprising the company’s top line came in at $62.8 million in the reported quarter, substantially up from the year-ago quarter’s $4 million. The top line also comprehensively beat the Zacks Consensus Estimate of $7 million.
On the third-quarter conference call, management stated that the surge in revenues was owing to recognition of the remaining deferred revenue as a result of terminating the Allergan collaboration.
We note that in August 2020, Editas terminated its 2017 agreement with Allergan [now part of AbbVie ABBV and regained the full global rights to develop, manufacture and commercialize its ocular medicines including the lead pipeline candidate EDIT-101.
In the third quarter, research and development expenses were $33.9 million, up 49.3% from the year-ago figure due to increased expenses related to the development of EDIT-101. General and administrative expenses increased 26.7% to $19.9 million owing to higher professional service expenses and personnel costs.
Shares of Editas were up 3% in after-hours trading following the earnings release on Thursday. In fact, the stock has rallied 6.6% in the year so far against the industry’s decrease of 1.1%.
Pipeline & Other Updates
Editas has no approved product in its portfolio at the moment. Therefore, its pipeline development remains in key focus for the company.
EDIT-101, which uses CRISPR gene editing technology, is being developed for treating Leber congenital amaurosis type 10 (LCA10), a rare genetic illness that causes blindness.
The company completed dosing the first cohort of the phase I/II BRILLIANCE study, which is evaluating EDIT-101 for LCA10.
Meanwhile, Editas initiated its investigational new drug (IND)-enabling activities for EDIT-301, an experimental CRISPR medicine, developed to treat sickle cell disease (SCD) and beta-thalassemia by editing the beta-globin locus. It plans to file the IND for EDIT-301 in the fourth quarter of 2020 for the SCD indication. The FDA granted Rare Pediatric Disease (RPD) designation to EDIT-301 for SCD in August 2020.
Editas Medicine, Inc. Price, Consensus and EPS Surprise
Editas Medicine, Inc. price-consensus-eps-surprise-chart | Editas Medicine, Inc. Quote
Zacks Rank & Stocks to Consider
Editas currently carries a Zacks Rank #3 (Hold). Better-ranked stocks in the biotech sector include Fulcrum Therapeutics, Inc. FULC and Halozyme Therapeutics, Inc. HALO, both carrying a Zacks Rank #2 (Buy) at present. You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.
Fulcrum Therapeutics’ loss per share estimates have narrowed 1.1% for 2020 and 0.9% for 2021 over the past 60 days.
Halozyme’s earnings estimates have been revised 19.7% and 13.7% upward for 2020 and 2021 each over the past 60 days. The stock has rallied 85.7% year to date.
5 Stocks Set to Double
Each was hand-picked by a Zacks expert as the #1 favorite stock to gain +100% or more in
MADRID (Reuters) – The number of coronavirus infections in Spain rose by 55,019 on Monday, the biggest increase since the start of the pandemic and more than double the increase of 25,595 new infections on Friday, health ministry data showed.
The death toll went up by 379, bringing the total number of coronavirus fatalities to 36,257 in Spain, which approved a six-month state of emergency last week to try to curb the second wave of contagion.
The 379 deaths was the sharpest one-day rise during the second wave, though still a far cry from nearly 900 at the peak of the first wave of the pandemic in late March.
The big jump in infections could partly be explained by an accumulation of cases over a three-day bank holiday weekend in Spain.
The official cumulative number of infections now stands at 1,240,697, but Prime Minister Pedro Sanchez has said the real total is likely to be above 3 million, based on prevalence studies and estimates.
The northern region of Asturias asked for permission on Monday from the Spanish government to impose a two-week home lockdown as the pressure on health services reached breaking point.
“What most worries is the rise in hospital cases, more than the first wave and above all in intensive care. This could push our health service to the limit,” Asturias regional president Adrian Barbón told a press conference.
However, Spain’s health minister Salvador Illa refused the region permission to impose a full lockdown, saying authorities in Asturias should wait to see the effects of a curfew and other restrictions imposed under the state of emergency.
Dr. Rafael Bengoa, co-founder of Bilbao’s Institute for Health and Strategy, predicted Spain would impose a home lockdown within two weeks because the rate of infection was not slowing down.
“With the current measures, they are not lowering the infection rates, and it is necessary to go to the next level, a March-April type confinement,” he told Catalunya Radio on Sunday.
(This story corrects to remove word “daily” from headline and first sentence)
(Reporting by Graham Keeley; Editing by Bill Berkrot and Bernadette Baum)
Copyright 2020 Thomson Reuters.
Soaring case counts around the country are impacting children at “unprecedented levels,” according to new numbers released Monday by the American Academy of Pediatrics and the Children’s Hospital Association, which are tracking data reported by state health departments.
There were 61,000 new cases in children during the last week of October, “which is larger than any previous week in the pandemic,” the AAP said in a statement. From the onset of the pandemic through October 29, more than 853,000 children have tested positive for Covid-19, the AAP said, including nearly 200,000 new cases during the month of October.
“This is a stark reminder of the impact this pandemic is having on everyone — including our children and adolescents,” said AAP President Dr. Sally Goza in the statement.
“This virus is highly contagious, and as we see spikes in many communities, children are more likely to be infected, too,” Goza said.
Yet these numbers are likely an undercount, the AAP said. Because symptoms in children are often mild and can look like common colds or viruses, many children go untested.
Symptoms in children
Typical symptoms of Covid-19 in both children and adults include a fever of 100 degrees Fahrenheit or higher, a dry cough, difficulty breathing, headaches, digestive issues, body aches and fatigue, runny nose, sore throat and sneezing.
Unusual symptoms can include “Covid toes” — a reddish tinge to toes and other extremities, a sudden loss of taste and smell and conjunctivitis, a highly contagious condition also known as pink eye.
However, early research has suggested children may not get fever, cough or shortness of breath as often as adults. Fever and cough was found in 56% and 54% of children in one study, compared to 71% and 80% of adults, according to the US Centers for Disease Control and Prevention. Shortness of breath was found in only 13% of pediatric patients, compared to 43% of adults. Sore throat, headache, muscle pain, fatigue and diarrhea were also less commonly reported in children.
While cases of severe illness due to Covid-19 appears to be rare among children, severe illness has been reported, most often in infants less than a year.
When children did need to be hospitalized, the CDC found, one in three needed to be treated in the intensive care unit — the same rate as for adults.
Long-term effects not known
Adolescents between the ages of 12 and 17, according to an early October report by the CDC, were about twice as likely to test positive for Covid-19 than kids between 5 and 11 years old.
More severe cases of Covid-19 were most likely to be found in children with underlying health conditions, the CDC said, with chronic lung disease, including asthma, the most commonly reported condition (55%). While in smaller percentages, children with disability (9%), immune disorders (7%), diabetes (6%), psychological conditions
Nov. 2 (UPI) — People who have high blood pressure at night are at increased risk for heart disease, even if their blood pressure is within normal ranges during the day, according to a study published Monday by the journal Circulation.
A nighttime systolic blood pressure — the “top” number — that is 20 millimeters of mercury — or mm. Hg, the unit of measure for blood pressure — above daytime readings raises a person’s risk for heart disease by 18%, the data showed.
That same rise in nighttime blood pressure also increases a person’s risk for heart failure by 25%, the researchers said.
“Nighttime blood pressure is increasingly being recognized as a predictor of cardiovascular risk,” study co-author Dr. Kazuomi Kario said in a statement.
“This study provides much more in-depth information about the cardiovascular risk associated with high nighttime blood pressure,” said Kario, a professor of cardiovascular medicine at Jichi Medical University in Japan.
Nearly half of all adults in the United States — or 108 million people — have high blood pressure, the Centers for Disease Control and Prevention estimates.
Research suggests that up to 40% of people experience rises in systolic blood pressure at night, whether or not their blood pressure is considered normal or healthy — between 90 mm. Hg and 120 mm. Hg — during the day.
For this study, researchers measured daytime and nighttime systolic blood pressure in 6,359 adults from across Japan between 2009 and 2017, using an at-home, wearable, ambulatory monitor.
Blood pressure was recorded during daily activities and sleep for at least 24-hours at a time, and device data were periodically downloaded at a healthcare clinic, the researchers said.
Nearly half of the study participants were male, and more than half were aged 65 years and older, according to the researchers.
All of the study participants had at least one risk factor for heart disease — although none had been diagnosed with it — and 75% of them were taking blood pressure medications when the study began, the researchers said.
The study participants were instructed to rest or sleep during nighttime hours and maintain their usual daytime activities, and they recorded their daily activities and sleep and wake times in a diary.
Nearly every participant recorded 20 daytime and seven nighttime automated blood pressure measurements.
By the end of the study period, participants experienced a total of 306 cardiovascular events, including 119 strokes, 99 diagnoses of coronary artery disease and 88 diagnoses of heart failure.
Those with a disrupted circadian blood pressure rhythm — or higher blood pressure at night than during the day — had a 48% higher risk for heart disease and were nearly three times as likely to experience heart failure, the data showed.
Circadian rhythms are the body’s natural, internal process that regulates a person’s sleep-wake cycle and repeats with each rotation of the Earth, or roughly every 24 hours, according to the American Heart Association.
Blood pressure typically fluctuates with a pattern that follows the
Los Angeles County public health officials on Sunday reported 1,590 new cases of the coronavirus and four related deaths.
The numbers brought the county’s total to 309,197 cases and 7,074 deaths.
There were 799 confirmed coronavirus patients in county hospitals on Friday, with 28% in intensive care, officials said. Though hospitalizations have increased slightly, they remain far below the 2,220-plus patients seen during the peak of the outbreak in July.
Still, many Southern California communities are reporting increases in the number of cases recorded each day, a concerning trend that has some officials worried that transmission of the virus could be on the rise.
In order to determine when a county can move to the next phase of reopening under California’s four-tier plan, the state monitors how many cases have been reported per 100,000 residents over a recent seven-day period. In larger counties, the rate is adjusted to account for how much testing is being done.
L.A. County’s adjusted case rate increased last week to eight per 100,000 residents, from 7.6 the week before.
In Orange County, which reported 233 new coronavirus cases and one death Sunday, the case rate ticked up to 5.1 from 4.6 the week before. Riverside County reported its most recent adjusted case rate at 10.1, up from 9.1 the week before. And San Bernardino County reported an adjusted case rate of 11.9, up from 10.9.
L.A., Riverside and San Bernardino counties all remain in the purple tier, the most restrictive, meaning risk of transmission remains widespread, and most nonessential businesses are closed for indoor operations. To move into the next tier, red, a county must have an adjusted rate of no more than seven cases per 100,000 residents.
Orange County is classified within the red tier. In order to move into the less-restrictive orange tier, which means that the risk of transmission is considered moderate and some indoor business operations can resume with modifications, the county must reduce its adjusted case rate to four cases per 100,000 residents.
It’s not clear what is driving the increase in cases in Southern California. Some officials have blamed parties as likely contributors, particularly gatherings celebrating the recent Lakers and Dodgers wins.
The trend is also playing out elsewhere across the United States, which on Thursday broke the single-day record for the highest number of coronavirus cases, then did so again Friday.
This story originally appeared in Los Angeles Times.
Coronavirus infections soared this week to record levels, hospitalizations are up in almost every state, and now — predictably, but slowly — deaths are rising, too.
The nation passed another milestone Friday with 9 million confirmed cases since the start of the pandemic, including more than 98,000 new cases, a daily record. More than 1,000 deaths in the United States from the novel coronavirus were reported each day Wednesday and Thursday, according to health data analyzed by The Washington Post, continuing an upward trend that began two weeks ago.
All signs indicate that this isn’t a blip but rather a reflection of a massive surge in infections that, without a dramatic effort to reverse the trend, will drive up the death toll for weeks to come. At least 229,000 people in the United States have died of covid-19, the disease caused by the virus.
But the mortality numbers have become political fodder on the campaign trail. Depending on whom you listen to, the coronavirus just isn’t that deadly anymore. Or it’s killing people in droves.
The truth is that mortality rates have improved, but the accelerating spread of the virus is driving up the absolute numbers of deaths.
Doctors have reported better outcomes thanks to improved techniques for treating patients and the use of the steroid dexamethasone and the antiviral remdesivir. In a widely reported study, researchers at NYU Langone Health found that the death rate among more than 5,000 patients in the system’s three hospitals dropped from 25.6 percent in March to 7.6 percent in August.
Still, this remains a potentially deadly disease, and a large proportion of the population is still vulnerable to infection. With the number of infections hitting daily records, there is reason to expect that deaths will keeping rising until the spread of the virus is contained.
Deaths lag infections by many weeks. In hard-hit North Dakota, daily infections have doubled since the end of September, while the average number of deaths from covid-19 is up 50 percent. In Indiana, cases are up 150 percent in that time, and deaths are up 93 percent.
In Wisconsin, cases began spiking in early September, and deaths began to rise sharply at the end of the month. Of the 2,029 deaths there from the pandemic, more than half have occurred since Sept. 25.
President Trump and his son Donald Trump Jr. have in recent days said there has been an excessive focus on infections rather than deaths, which have not risen as quickly and remain lower than in the early days of the pandemic.
“Do you ever notice, they don’t use the word ‘death’? They use the word ‘cases,’ ” the president said Tuesday in Omaha.
NORWALK, CT — Norwalk is reverting to Phase 2 reopening efforts, as the city grapples with a continued rise in coronavirus (COVID-19) cases, Mayor Harry Rilling announced Thursday. The rollback will take effect at noon on Nov. 1 to allow businesses to prepare.
The city was placed on red alert status last week by Gov. Ned Lamont and state health officials, due to Norwalk exceeding 15 new coronavirus cases per 100,000 people. The number of red alert communities in Connecticut now stands at 30, up from 19 last week, according to the state.
At that time, the city’s rate of infection was 18.9 new coronavirus cases per 100,000, but that number more than doubled to 40.5 and then to 48.9 per 100,000 between Oct. 18 and Oct. 24. Norwalk also reported its first coronavirus-related deaths this week, after more than three weeks without one.
To date, 151 Norwalk residents have died as a result of the virus.
This week, Rilling has been under quarantine due to exposure to a family member who tested positive for COVID-19. The mayor has tested negative twice since then.
As of Thursday, 54 new coronavirus cases were reported in Norwalk, bringing the city’s total to 2,984 since the pandemic began in March, according to health officials. No new deaths were reported.
The city was at Phase 3 reopening, which meant restaurants, personal services, gatherings and sporting events could operate at 75 percent capacity. On Nov. 1, that number rolls back to 50 percent.
Additionally, Phase 2 also calls for:
Private gatherings to drop from 100 people to 25 people indoors, and 150 people to 100 people outdoors
Religious gatherings to decrease from up to 200 people to a maximum of 100 people indoors
“This is a difficult decision, as I do not want to see our local businesses impacted, but my priority remains the health and safety of our residents,” Rilling said. “Our cases are rising, and I am deeply concerned. We are now seeing increased cases for those over 70 years of age, and we know this population is at higher risk of serious illness and death from this virus.”
The city will host another free, drive-thru coronavirus testing session on Saturday between 10 a.m. and 2 p.m. in the parking lot at Norwalk Community College on Richards Avenue.
“We have ramped up testing to try to slow this virus down, but it continues to spread rapidly, as people are not following all public health guidelines,” Rilling said. “Residents must take this seriously. Please, stay home if you can, limit travel and errands whenever possible, and always wear a face covering in public.”
This article originally appeared on the Norwalk Patch