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The Alliance for Regenerative Medicine Announces Record Sector Financing in 2020

The regenerative medicine sector attracted $15.9 billion in financing through just the first three quarters of the year, shattering the previous record of $13.5 billion

Washington, DC, Nov. 19, 2020 (GLOBE NEWSWIRE) — via NewMediaWire — Global financing for the regenerative medicine and advanced therapy sector set an annual record of $15.9 billion through just the first three quarters of 2020, according to data released today by the Alliance for Regenerative Medicine (ARM), the leading international advocacy organization dedicated to realizing the promise of regenerative medicines.

Despite the COVID-19 pandemic, financing for the cell, gene, and tissue-based therapies sector surpassed the previous record of $13.5 billion set during full-year 2018.

“There is strength across all types of investment and stages of the pipeline, from early-stage cell-based immuno-oncology to late-stage gene therapies,” said Janet Lambert, CEO of ARM. “The outlook for patients has never been brighter.”

Investors remain bullish about the promise of profound, durable, and possibly curative regenerative medicines to treat a range of diseases and disorders.

Public financing continues to drive the sector, through both IPOs ($2.8 billion YTD) and follow-on financings ($5.7 billion YTD). At $4.1 billion year-to-date, venture capital financing is also on track to surpass the previous record of $4.3 billion set in 2019.

“The rapid advancement of the science behind regenerative medicine makes this a very dynamic time for investors and a hopeful time for patients,” said Jason Rhodes, a partner at Atlas Venture. “The breadth of approaches now available — from CRISPR to CAR-Ts to lentiviruses and non-viral gene therapies — enables us to pick the right tool for the specific biology that we’re addressing.”

Highlights from ARM’s third-quarter 2020 data include:

Gene therapy financing was $3.5B in Q3 2020 and $12 billion YTD, up 178% and 114% from 2019 levels respectively; cell therapy financing reached $3 billion in Q3 2020 and $11 billion YTD, up 97% and 242%, respectively; tissue-based therapy financing was $226 million in Q3 2020 and $311 million YTD, up 11% and 311% respectively.*

At the end of Q3 2020, there were 1,109 regenerative medicine clinical trials ongoing worldwide – 373 in gene therapy, 492 in cell-based immuno-oncology, 202 in cell therapy, and 42 in tissue-based therapies.

Of the 1,109 clinical trials, 388 target more prevalent diseases, including prevalent cancers (159), cardiovascular disease (35), diseases of the central nervous system (33), infectious diseases including COVID-19 (38), and diabetes (17).

There are 97 ongoing Phase 3 clinical trials, with regulatory decisions expected in the coming months in the US and Europe for several product candidates across cell, gene, and tissue-based therapies; cell-based immuno-oncology now comprises more than half of the 418 Phase 1 trials.

There are 1,026 regenerative medicine and advanced therapy developers active globally, up from 1,001 in our previous report covering the first half of 2020. Of the current total, 536 are active in gene therapy, 641 are active in cell therapy, and 135 are active in tissue-based therapies.

* Some companies utilize multiple technology types, and financings for

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Spain Sets Record COVID-19 Case Rise With Over 55,000 New Infections: Health Ministry | World News

MADRID (Reuters) – The number of coronavirus infections in Spain rose by 55,019 on Monday, the biggest increase since the start of the pandemic and more than double the increase of 25,595 new infections on Friday, health ministry data showed.

The death toll went up by 379, bringing the total number of coronavirus fatalities to 36,257 in Spain, which approved a six-month state of emergency last week to try to curb the second wave of contagion.

The 379 deaths was the sharpest one-day rise during the second wave, though still a far cry from nearly 900 at the peak of the first wave of the pandemic in late March.

The big jump in infections could partly be explained by an accumulation of cases over a three-day bank holiday weekend in Spain.

The official cumulative number of infections now stands at 1,240,697, but Prime Minister Pedro Sanchez has said the real total is likely to be above 3 million, based on prevalence studies and estimates.

The northern region of Asturias asked for permission on Monday from the Spanish government to impose a two-week home lockdown as the pressure on health services reached breaking point.

“What most worries is the rise in hospital cases, more than the first wave and above all in intensive care. This could push our health service to the limit,” Asturias regional president Adrian Barbón told a press conference.

However, Spain’s health minister Salvador Illa refused the region permission to impose a full lockdown, saying authorities in Asturias should wait to see the effects of a curfew and other restrictions imposed under the state of emergency.

Dr. Rafael Bengoa, co-founder of Bilbao’s Institute for Health and Strategy, predicted Spain would impose a home lockdown within two weeks because the rate of infection was not slowing down.

“With the current measures, they are not lowering the infection rates, and it is necessary to go to the next level, a March-April type confinement,” he told Catalunya Radio on Sunday.

(This story corrects to remove word “daily” from headline and first sentence)

(Reporting by Graham Keeley; Editing by Bill Berkrot and Bernadette Baum)

Copyright 2020 Thomson Reuters.

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More Than 61,000 Children Tested Positive for COVID-19 Last Week, Setting New 7-Day Record

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More than 61,000 children in the U.S. tested positive for COVID-19 last week, setting a new high for any 7-day span since the beginning of the pandemic, new numbers show.

On Monday, the American Academy of Pediatrics and the Children’s Hospital Association reported that 61,447 children contracted the coronavirus from Oct. 22 to Oct. 29.

This number is “larger than any previous week in the pandemic,” the organization, which is tracking weekly COVID numbers using state health department data, said in a statement.

The AAP found that the percentage of cases in children has been on the rise since mid-April.

RELATED: U.S. Hits Highest Single-Day Number of COVID-19 Cases for Any Country, England to Enter Lockdown

Since the onset of the pandemic, 853,635 children have tested positive for the coronavirus, representing 11.1 percent of all cases in the U.S.

In October alone, nearly 200,000 new pediatric cases of COVID-19 were reported.

“This is a stark reminder of the impact this pandemic is having on everyone — including our children and adolescents,” Dr. Sally Goza, president of the AAP, said in a news release.

“This virus is highly contagious, and as we see spikes in many communities, children are more likely to be infected, too,” she added.

The AAP noted that this record number is most likely an undercount as children’s symptoms are often mild and they might not test for the virus.

RELATED: 13-Year-Old Missouri Boy Dies from COVID-19 Complications: ‘He Was So Very Sweet and Caring’

While severe illness due to COVID-19 is rare among children, the AAP notes an urgent need to collect more data on longer-term impacts on kids.

“Not only are children feeling the direct effects of the virus and becoming ill, but the pandemic has transformed their lives at critical stages of development and education,” Dr. Goza added.

“I’m very concerned about the long-term harms that children may suffer, particularly Black and Hispanic children, who are suffering a higher number of infections,” she continued. “This includes not only children who test positive for the virus, but everyone in these communities who are suffering disproportionate emotional and mental health harms.”

The AAP urges people to continue social distancing, wearing masks and following other public health recommendations to further protect children and their communities.

As information about the coronavirus pandemic rapidly changes, PEOPLE is committed to providing the most recent data in our coverage. Some of the information in this story may have changed after publication. For the latest on COVID-19, readers are encouraged to use online resources from the WHO and local public health departments. PEOPLE has partnered with GoFundMe to raise money for the COVID-19 Relief Fund, a GoFundMe.org fundraiser to support everything from frontline responders to families in need, as well as organizations helping communities. For more information or to donate, click here.

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Coronavirus cases in North Dakota reach record high

The number of confirmed, active cases of the novel coronavirus in North Dakota has surged, reaching the highest levels since the deadly virus was first identified in the Midwestern state. 

As of Monday, North Dakota reported 8,440 active cases of COVID-19, the highest amount since the state began tracking cases in March. The high includes an estimated 975 newly confirmed active cases, raising the state’s daily positivity rate to 12.62%, per state health data. 

The news comes after North Dakota health officials in late October asked residents to conduct their own contact tracing if they have tested positive for COVID-19 as a surge in cases of the novel coronavirus has left contact tracers in the state overwhelmed and strapped for resources. (iStock)

The news comes after North Dakota health officials in late October asked residents to conduct their own contact tracing if they have tested positive for COVID-19 as a surge in cases of the novel coronavirus has left contact tracers in the state overwhelmed and strapped for resources. (iStock)

Overall, the state has reported more than 46,000 cases of the deadly virus and some 540 deaths. 

The news comes after North Dakota health officials in late October asked residents to conduct their own contact tracing if they have tested positive for COVID-19 as a surge in cases has left contact tracers in the state overwhelmed and strapped for resources. 

CORONAVIRUS CASES IN TEXAS SURPASS 900,000, STATE DATA SHOWS

In a news release, the North Dakota Department of Health announced it added some 400 contact tracers and case investigators over the summer to help “quickly trace and quarantine close contacts, allowing contact tracing to continue long after many other states had to suspend their efforts.” 

But a “sharp increase” in COVID-19 cases in recent weeks “put increased pressure on contact tracing teams at the state and local level, leading to tracing delays and a backlog of positive cases that have yet to be assigned to a case investigator,” they said at the time. 

ARE POLL WORKERS AT AN INCREASED RISK FOR CORONAVIRUS?

Officials also noted that it will take longer for those who have been tested for the novel coronavirus to learn their results. Patients will be notified 72 hours from when the lab confirms their result compared to the past wait time of 24 hours. 

“In addition, significant community spread of coronavirus and a lack of compliance with close contact investigations have diminished the effectiveness of contact tracing,” health officials said at the time. 

CLICK HERE FOR COMPLETE CORONAVIRUS COVERAGE 

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New Hampshire Reports Record High Positive COVID-19 Test Results

CONCORD, NH — Gov. Chris Sununu, R-NH, issued a weekend statement Saturday after state health officials reported the highest single day of new COVID-19 positive test results — 205, including 31 children.

The new test results were reported after 7,927 specimens were collected Friday and prior days of tests were updated slightly from previous reports. A little more than 1,100 test results are pending for a polymerase chain reaction test positivity rate of 1.6 percent.

“The situation here in New Hampshire remains very serious, the data shows that community transmission is increasing, and we expect cases to rise,” Sununu said. “We must all remain vigilant in our daily lives. As we enter these winter months, it will be more important than ever to wear your mask, practice social distancing, and maintain proper hand hygiene.”

Nearly a quarter of the new test results, 50, came from Rockingham County with 27 living in Hillsborough County outside of Manchester and Nashua, 19 residing in Nashua, and 13 living in Merrimack.

State officials are still investigating the residency of eight cases.

Fifty-three percent of the new positive test results were female.

The state reported that 42 people are currently hospitalizations while only one of the new cases has no identified risk factors.

Accumulatively, 11,084 people have contracted COVID-19 in New Hampshire with 1,338 currently infected and 9,263, 84 percent, having recovered from the virus.

The State Joint Information Center also announced the 483rd death in the New Hampshire — a woman who was 80 years of age or older and lived in a long-term care setting in Hillsborough County.

More than 345,000 people have been tested for the coronavirus with nearly 617,00 PCR tests being administered by the state and 4,400 people under public health monitoring.

More Possible Restaurant Exposures

Both state and Nashua health officials issued alerts during the past 24 hours about possible restaurant exposure to the public.

Nashua Public Health is investigating potential community exposure related to a person with a confirmed COVID-19 diagnosis at the Texas Roadhouse on 580 Amherst St. The potential community exposure occurred in the bar area between 3 and 10 p.m. on Oct. 22, and 11 a.m. to close on Oct. 23.

“The health and safety of our staff and customers is our top priority,” Eric Martin, the restaurant’s director of food safety. “We have been following CDC guidelines for cleaning and disinfecting our facility. We follow all reopening guidance for food service establishments from the state.”

Public health is investigating the situation and notifying any known close contacts directly but if you were at the restaurant during those dates, you should self-quarantine, monitor for symptoms — sore throat, congestion, runny nose, headache, muscle ache, fatigue, new loss of taste or smell, fever, cough, shortness of breath, nausea, vomiting, or diarrhea, and get tested.

State health officials said contact tracers were investigating another possible community exposure in Merrill’s Tavern and Stagecoach Grille at the Atkinson Resort & Country Club between 11 a.m. and 11:30

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Illinois sets record for coronavirus cases for third day in a row

Illinois continues to shatter records for new known coronavirus cases, setting another high mark for the third day in a row.

State public health officials on Saturday reported 7,899 new COVID-19 cases, eclipsing Friday’s single-day record of 6,943 cases. On Thursday, the state reported 6,363 cases, which set a record at the time.

Along with the record number of new cases, state health officials announced 46 more fatalities on Saturday bringing the statewide death toll to 9,757 since the pandemic began.

The high number of cases comes as Public Health Director Dr. Ngozi Ezike urged people to make “pandemic-guided decisions” and to avoid in-person gatherings on Halloween weekend.

Ten of 11 Illinois regions are now operating under tighter restrictions under Gov. J.B. Pritzker’s reopening plan, including a ban on indoor dining and bar service, as the coronavirus continues its statewide resurgence.

A chunk of east-central Illinois that includes Champaign-Urbana and Decatur is the latest to join the list after its seven-day rolling positivity rate on coronavirus tests hit 8.6% on Tuesday, exceeding the state-established threshold of 8% for the third straight day and triggering the reopening rollback. The restrictions also include a 25-person limit on gatherings, down from 50.

The return of restrictions has proved controversial, with some restaurants vowing to continue indoor dining. Pritzker ordered closures for indoor dining last week in DuPage, Kane, Will and Kankakee counties. A similar restriction took effect in suburban Cook County on Wednesday and in Chicago on Friday. Lake and McHenry counties are to follow Saturday.

The state has reported 410,300 confirmed infections since the pandemic began. The seven-day statewide positivity rate, covering Oct. 24-30, — is 7.5%.

———

©2020 the Chicago Tribune

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Coronavirus Live Updates: New U.S. Cases Hit Fresh Record

Nearly 46 million people have now been infected with the coronavirus world-wide, and nearly 1.19 million have died.

U.K.: Prime Minister Boris Johnson’s cabinet was due to meet Saturday to discuss plans for a new nationwide lockdown in England to curb the virus’s spread, according to a government official, who stressed a final decision hasn’t been made. Scientists at Imperial College London estimate infections are running at almost 100,000 a day in England, and hospitalizations and deaths are creeping up. The seven-day average for deaths hit 213 on Tuesday, its highest tally since May.

The government has been experimenting with localized restrictions in England but cases have continued rising. Scotland, Wales and Northern Ireland set their own public-health policies and have already closed some businesses and imposed curbs on household mixing. Mr. Johnson is due to hold a televised press conference at 4:00 p.m. London time on Saturday.

Greece: New restrictions, including mandatory mask wearing indoors and outdoors, will be take effect in Greece starting Tuesday. Other measures include a midnight to 5 a.m. curfew, and university courses will revert to online learning. In the Athens region and northern Greece, where the virus is circulating at higher levels, the government has also ordered the closure of bars, restaurants, theaters, museums and gyms.

While Greece has among the lowest infection rates in Europe, new cases are rising rapidly. Announcing the new measures, Greek Prime Minister Kyriakos Mitsotakis said the goal was to prevent the virus from spreading out of control.

“We must act now, before the intensive-care units are overwhelmed by people fighting for their life. Now, while we still have the ability to detect and track cases,” he said in a televised address.

India: The new-case count was below 50,000 for the sixth day in a row, with the country reporting 48,268 cases over the preceding 24 hours, and 551 deaths. Confirmed cases now exceed 8.1 million, with a death toll of 121,641.

Japan: The 778 new cases reported Saturday pushed the total past 100,000, and the 11 deaths brought the toll to 1,755. Starting Sunday, the government will allow business travelers returning from trips of seven days or less to any country to skip the two-week quarantine, provided they meet conditions including a negative test result.

The government has also lowered travel alerts on nine countries including China, South Korea and Australia. From Sunday onward, travelers from those countries won’t be required to take a coronavirus test upon arrival.

South Korea: With 127 new Covid-19 cases reported, it was the fourth consecutive day above 100. Locally transmitted infections have been rising this week, with new clusters around workplaces and social gatherings. Local authorities are on high alert this weekend, concerned that Halloween festivities could prompt a fresh wave.

China: Mainland Chinese authorities reported six new locally transmitted symptomatic cases, all in and around the city of Kashgar in the far western Xinjiang region and previously classified as asymptomatic. Chinese health authorities typically highlight and focus on positive cases showing

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US shatters daily coronavirus record with nearly 90,000 new infections

The US has shattered the daily coronavirus record, with almost 90,000 new infections reported on Thursday and close to 1,000 deaths, as the country surged past a world-topping 9m cases and experts warned of death rates more than doubling by mid-January.



a person wearing a costume: Photograph: Elaine Thompson/AP


© Provided by The Guardian
Photograph: Elaine Thompson/AP

The sobering data and scientific outlook show a pandemic veering further out of control in America even as the president and his son hammered a public message dismissing the grim realities.

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On Friday, the total number of cases in the US hit 9,018,000, according to figures from Johns Hopkins University. So far, 228,677 people have died in the country, the highest figure in the world by a significant margin.

The US recorded its highest one-day total of new coronavirus infections of the pandemic, with 88,521 new cases reported on Thursday – a rise of 9,540 on the previous day. The death toll for the 24-hour period was 971.

Hospitalisations are soaring in all but 11 states, according to the Covid Tracking Project, with more than 46,000 people in hospital on Thursday and a number of states setting up overflow field hospitals and governors sending military helpers.

Donald Trump responded to the surge with a Friday morning tweet blaming case numbers on increased testing. “More Testing equals more Cases. We have best testing. Deaths WAY DOWN. Hospitals have great additional capacity! Doing much better than Europe. Therapeutics working!”



a person wearing a costume: Hospitalisations are soaring in all but 11 states, according to the Covid Tracking Project, with more than 46,000 people in hospital on Thursday.


© Photograph: Elaine Thompson/AP
Hospitalisations are soaring in all but 11 states, according to the Covid Tracking Project, with more than 46,000 people in hospital on Thursday.

His eldest son, Donald Trump Jr, said in an interview on Fox that deaths were “almost nothing”.

Related: Donald Trump Jr and father play down Covid deaths as daily toll nears 1,000

But experts warned that conditions are likely to worsen sharply going into winter and predicted that death rates could more than double by mid-January.

The Institute for Health Metrics and Evaluation at the University School of Medicine said in its latest forecast that the death toll could hit 514,000 by the middle of January and added it was most likely that by that time 2,250 Americans will be dying every day from Covid-19, more than twice the current rate.

“The fall/winter surge should lead to a daily death toll that is approximately three times higher than now by mid-January. Hospital systems, particularly ICUs, are expected to be under extreme stress in December and January in 18 states,” it said.

The president continued to insist that the US was “rounding the turn”, arguing against taking stricter measures to combat the pandemic and told a campaign rally on Saturday “you don’t see death”.

“This is the hardest point in this pandemic right now – the next two months,” Scott Gottlieb, the former commissioner of the US Food and Drug Administration (FDA), told CNN.

But with the election just days away, cases are soaring in every competitive state. In 13 potential swing states the weekly average

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US records 97,000 new COVID-19 cases, shattering daily record

The U.S. recorded roughly 97,000 new coronavirus cases Friday, shattering the previous record for the highest number of new cases in a single day.



a man riding a skateboard up the side of a road: coronavirus COVID-19 third wave community spread peak spring summer fall anthony fauci trump pandemic time graphic data record breaking daily cases


© Getty Images
coronavirus COVID-19 third wave community spread peak spring summer fall anthony fauci trump pandemic time graphic data record breaking daily cases

Data from the COVID Tracking Project showed there were 97,080 new cases Friday, ushering in an alarming new milestone that comes as dozens of states across the country see spikes in infections. The figure broke the previous record of 88,521 new coronavirus cases, which had been set on Thursday.

The nationwide surge in cases comes just ahead of a winter season during which experts say the increase will be exacerbated, as social gatherings move indoors where the virus can spread more easily.

“This is the hardest point in this pandemic right now – the next two months,” Scott Gottlieb, the former commissioner of the Food and Drug Administration, said during an interview on CNBC’s “Squawk Box” on Thursday. “We can’t give up our guard right now.”

The rise in cases virtually confirms that the coronavirus pandemic will be a top issue in the election next week, with polls showing large swaths of voters already saying the virus outbreak is their No. 1 issue.

The most serious outbreaks are being found in crucial political battlegrounds in the Midwest, including Wisconsin, which saw more than 5,000 new cases Friday.

The president has maintained the country is “rounding the turn,” but Democrats have torn into the Trump administration’s response to the pandemic, noting his dismissal of guidance from government health experts.

“President Trump’s decision to mislead the public about the severity of the crisis, his failure to listen to scientists about how to keep Americans healthy, and his refusal to implement a coordinated national plan to stop the coronavirus have all contributed to devastating results: more than 227,000 Americans dead, more than 8.8 million Americans infected, and a dangerous virus that continues to spread out of control nine months after it reached our nation’s shores,” a report from the House Select Subcommittee on the Coronavirus Crisis said Friday.

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US shatters daily coronavirus record with nearly 90,000 new infections Thursday

The US has shattered the daily coronavirus record, with almost 90,000 new infections reported on Thursday and close to 1,000 deaths, as the US approached a world-topping 9m cases and experts warned of death rates more than doubling by mid-January.



a person wearing a costume: Photograph: Elaine Thompson/AP


© Provided by The Guardian
Photograph: Elaine Thompson/AP

The sobering data and scientific outlook show a pandemic veering further out of control in America even as the president and his son hammered a public message dismissing the grim realities.

According to figures from Johns Hopkins University of Medicine, the US had a total of more than 8.9 million cases on Friday, and was expected to soon cross the nine million mark. So far 228,677 people have died, the most in the world by a significant margin.

The USrecorded its highest one-day total of new coronavirus infections of the pandemic, with 88,521 new cases reported on Thursday – a rise of 9,540 on the previous day. The death toll for the 24-hour period was 971.

Hospitalisations are soaring in all but 11 states, according to the Covid Tracking Project, with more than 46,000 people in hospital on Thursday and a number of state setting up overflow field hospitals and governors sending military helpers.

Donald Trump responded to the surge with a Friday morning tweet blaming case numbers on increased testing. “More Testing equals more Cases. We have best testing. Deaths WAY DOWN. Hospitals have great additional capacity! Doing much better than Europe. Therapeutics working!”



a person wearing a costume: Hospitalisations are soaring in all but 11 states, according to the Covid Tracking Project, with more than 46,000 people in hospital on Thursday.


© Photograph: Elaine Thompson/AP
Hospitalisations are soaring in all but 11 states, according to the Covid Tracking Project, with more than 46,000 people in hospital on Thursday.

His eldest son, Donald Trump Jr, said in an interview on Fox that deaths were “almost nothing.”

Related: Donald Trump Jr and father play down Covid deaths as daily toll nears 1,000

But experts warned that conditions are likely to worsen sharply going into winter and predicted that death rates could more than double by mid-January.

The Institute for Health Metrics and Evaluation at the University School of Medicine said in its latest forecast that the death toll could hit 514,000 by the middle of January and added it was most likely that by that time 2,250 Americans will be dying every day from Covid-19, more than twice the current rate.

“The fall/winter surge should lead to a daily death toll that is approximately three times higher than now by mid-January. Hospital systems, particularly ICUs, are expected to be under extreme stress in December and January in 18 states,” it said.

The president continued to insist that the country is “rounding the turn”, arguing against taking stricter measures to combat the pandemic and told a campaign rally on Saturday “you don’t see death”.

“This is the hardest point in this pandemic right now – the next two months,” Scott Gottlieb, former commissioner of the US Food and Drug Administration (FDA), told CNN.

But with the election just days away, cases are soaring in every competitive state. In 13 potential

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