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QurAlis to Present Data on Two Precision Medicine Programs (Kv7 and TBK1) at MNDA 31st International Symposium on ALS/MND – Press Release

CAMBRIDGE, Mass.–(Business Wire)–QurAlis Corporation, a biotech company focused on developing precision medicines for amyotrophic lateral sclerosis (ALS) and other neurologic diseases, today announced that the company will present two posters featuring data from two of the company’s preclinical precision medicine ALS programs at the Motor Neuron Disease Association (MNDA) 31st International Symposium on ALS/MND, being held virtually on December 9-11, 2020.

QurAlis co-founders and Harvard professors Kevin Eggan, Ph.D. and Clifford Woolf, M.D., Ph.D., members of the QurAlis Scientific and Clinical Advisory Boards, Brian Wainger, M.D., Ph.D. (Massachusetts General Hospital) and Merit Cudkowicz, M.D., M.Sc. (Massachusetts General Hospital), and other authors recently published in JAMA Neurology the results of a clinical study investigating the therapeutic potential of Kv7 agonism in ALS. The clinical data support QurAlis’ belief that a safe Kv7 opener could be an effective disease-modifying therapy for ALS patients with motor system hyperexcitability, an approach that QurAlis is pursing with its preclinical program investigating the regulation of the Kv7.2/7.3 ion channel.

The poster presentations will share, for the first time publicly, results from preclinical studies of QurAlis’ program investigating a novel Kv7.2/7.3 ion channel agonist as a potential treatment for motor neuron hyperexcitability and excitotoxicity, as well as its program targeting the TBK1 autophagy pathway.

“While KV7 agonists have shown great potential as a treatment for the 20-50% of ALS patients who present with hyperexcitability in their motor system, they can often cause undesired side effects such as dizziness and fatigue,” said Daniel Elbaum, Ph.D., Chief Scientific Officer of QurAlis. “The preclinical data we will be presenting show that the improved channel specificity of our novel Kv7.2/7.3 agonist could translate into an improved clinical safety profile with significant reduction in off-target adverse events. We look forward to sharing the full results of this preclinical study as well as discussing our autophagy program at the MNDA 31st International Symposium on ALS/MND.”

Details of the presentations are as follows:

Title: TBK1 Autophagy Pathway Disease Mechanisms in ALS

Authors: Erika Norabuena; Clinton Bourbonais; Kasper Roet, Ph.D.; Kevin Eggan, Ph.D.; Daniel Elbaum, Ph.D.; Sandy Hinckley, Ph.D.

Presenting Author: Erika Norabuena

Date/Time: December 9, 2020, 12:10pm-12:50pm ET

Poster/Abstract Number: TST-07

Link to abstract

Title: QRA-244 a Potent, Selective KCNQ2/3 Opener and a Potential Therapy for Motor System Hyperexcitability induced Disease Progression in ALS patients

Authors: Daniel Elbaum, Ph.D.; Sandy Hinckley, Ph.D.; Kasper Roet, Ph.D.

Presenting Author: Daniel Elbaum, Ph.D.

Date/Time: December 11, 2020, 7:05am-7:50am ET

Poster/Abstract Number: TST-20

Link to abstract

About ALS

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease impacting nerve cells in the brain and spinal cord. ALS breaks down nerve cells, reducing muscle function and causing loss of muscle control. ALS can be traced to mutations in over 25 different genes and is often caused by a combination of multiple sub-forms of the condition. Its average life expectancy is three years, and there is currently no cure for the disease.

About QurAlis Corporation

QurAlis is bringing hope to the

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fitness

Anna Victoria’s Postpartum Journey Inspired Her to Launch New Programs On Her Fitness App

2020 has been a big year for Anna Victoria. On the personal front, after a two-year battle with infertility, the Fit Body Guides creator welcomed her first child, Aurora Vittoria Ferretti, in August.



a group of people posing for a photo: Anna Victoria


© Provided by Shape
Anna Victoria

But Victoria has been busy at work, too. She’s been developing a series of updates to her Fit Body app, including the launch of a pregnancy workout program and the introduction of three new trainers.

Victoria says being a first-time mom motivated her to bring something new to the Fit Body app that would specifically cater to her fellow mamas. “You hear about how hard being a mom is, but you really can’t comprehend it until you go through it yourself,” she tells Shape. “There are so many emotions and so many new things you have to learn — and in the midst of it all, you’re constantly feeling like you’re doing something wrong.”

In addition to emotional ups and downs, Victoria says she’s had some physical challenges during her postpartum journey as well. One week after her (unplanned) C-section in August, she says, she couldn’t even sit up on her own. “It took me two weeks to walk without pain,” she shares. “When you have a newborn, you don’t expect to be going through that. It’s a lot to juggle, which has, at times, been very hard.” (Related: 7 Moms Share What It’s Really Like to Have a C-Section)



a group of people posing for a photo: Along with a new pregnancy-focused workout program, the trainer will also be welcoming three new trainers to the Fit Body app.


© Anna Victoria
Along with a new pregnancy-focused workout program, the trainer will also be welcoming three new trainers to the Fit Body app.

It wasn’t until she was three weeks postpartum that Victoria started feeling more like herself again, she says. “Every week since then, I’ve gotten exponentially better,” she explains.

But when she was cleared by her doctor to work out again in September at around six weeks postpartum, Victoria knew she wasn’t physically capable of diving back in just yet. “I couldn’t even think about it,” she says. “I know my body and I just wasn’t ready.”

Instead, from weeks 6-8, Victoria says she focused on breathing techniques to start feeling in tune with her body again. “I felt like building a mind-muscle connection with my core was a good place to start,” she says. (Related: Fitness Influencer Anna Victoria Fights Back Against Pregnancy Workout Shaming)

The following week, Victoria started inching her way back into a workout routine. Her first “true” workout, she says, was a beginner-level, low-impact lower-body workout from her Fit Body app. “I even ditched the weights, but I still couldn’t walk for a week [after that first workout],” she admits. “I didn’t expect to be that sore! It was so hard.”

The experience was not only humbling for Victoria, a seasoned trainer, but it also inspired her to bring more pregnancy-, postpartum-, and beginner-friendly workouts to the Fit Body app — plus a new group of trainers to teach them.

What to Expect From the New Fit Body App Updates

If

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fitness

Aditi Chauhan’s academy launches online sports coaching & fitness programs- The New Indian Express

By IANS

NEW DELHI: Indian goalkeeper Aditi Chauhan, who founded the She Kicks Football Academy in 2018 to provide a platform for female players to achieve their goals in professional football, has announced two online sports coaching and fitness programs for boys and girls.

The online programs, which are designed by Aditi, include ‘Score from Home’ (for football aspirants) and ‘Sweat It’ (for everyone looking to lead a healthy lifestyle).

Each of the sessions will be planned and conducted by trained professionals in the field and will be carried out through video conferencing tools. Aditi will be closely monitoring both the programs to ensure that the best quality services are provided.

The batch for each of the programs will comprise of 15 individuals and WhatsApp groups will be created for regular feedback and for various important notifications and downloadable content to be shared.

Feedback will be taken from the participants every week to ensure the quality of the programs. Both programs have no age limit. The sessions which will be one hour long will be organised on Wednesdays and Fridays.

Speaking on the programs, Aditi, who is represented by sports marketing firm Baseline Ventures said, “Maintaining fitness is crucial for everyone and therefore we have decided to organise two programs with one catering to individuals who want to learn the game of football and the other catering to participants who are looking to keep fit and healthy without concentrating on any specific sport.”

“After my friends and family came to me for guidance regarding health and fitness, I realised that many people want to be aware of the ways of leading a sustainable long-term healthy lifestyle and therefore we decided to create the Sweat It program for one and all,” she added.

Source Article

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fitness

Fitness Innovator Teams with Leading Fitness Platform to Enhance Customer Training Experience with In-App Exercise Programs

LITTLE CANADA, Minn., Oct. 20, 2020 /PRNewswire/ — As fitness app usage soars, with over 84 million consumers using apps in the US alone, Dragon Door announced they would be making their best-selling fitness content available on the TriadXP fitness platform and TriadXP.com.  Dragon Door will use TriadXP to convert their exercise routines into in-app workouts that are performed with the TriadXP app. The app’s voice and visual cues walk exercisers through all exercise routines guiding them on what to do, when, how many, or for how long. With guidance and tracking, customers  enhance their training experience and improve workout efficiency. And, since the TriadXP mobile fitness app tracks the user’s performance as they workout with minimal effort on the users part, it eliminates the need for other apps or pen and paper to track results.

“TriadXP supports virtually any kind of workout,” said John Du Cane, CEO of Dragon Door Publications. “As fitness innovators, we know that long-term results are usually the result of consistent goal setting and the consistent measurement of results. You get what you measure for, and the measurement motivates you to maintain your progress. In that regard, we see TriadXP as the perfect solution to help our customers optimize their workout results.”

Addressing the need for home-based and callisthenic workouts, the bestselling 16-week Get Strong program from fitness gurus Al Kavadlo and Danny Kavadlo will be the first program launched.

Dragon Door, credited with launching the modern kettlebell movement, is a publisher and online fitness retailer and provides advanced training and certification for fitness instructors. When searching for a partner who would provide the requisite technology platform from content conversion thru mobile app, Dragon Door found their answer with TriadXP. TriadXP knows fitness technology and delivers an optimal workout experience for a fitness enthusiast. The easy-to-use mobile fitness app and its versatility were critical in the decision. Equally important was TriadXP’s AI-driven conversion tools, which quickly convert content without needing any technical knowledge at Dragon Door.

“We are excited to partner with a leader like Dragon Door,” said Mike Elia, CEO of Triad Fitness Group. “They have a lot of great content, and we know their users will find it easier to work out and perform their routines on our TriadXP app.”

About Dragon Door Publications
Dragon Door Publications is a publisher of innovative fitness content that offers effective, safe, and proven methods for maintaining a high level of health and physical performance over the long-term. The company is best known for having launched the modern kettlebell movement in 2001. Learn more at www.dragondoor.com

About TriadXP.com
TriadXP.com, a fitness content platform from Triad Fitness Group, provides services and technology to allow content providers to convert text-based programs and related exercise imagery and videos into in-app exercise programs to be performed and tracked with the TriadXP mobile app. The app is free and compatible with iOS and Android devices. TriadXP is making workouts better for everyone. Learn more at www.triadxp.com

Contact: John Du

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